Centre for Tumour Biology

Our centre's researchers work on different aspects of the biology of transformed cells or the stromal cells found in neoplastic foci. We bring together individuals with a diverse range of expertise in cell biology, molecular biology and pathology to form a synergistic approach to complex biological problems. Our unifying interest is in understanding the cellular and molecular events which drive tumour progression to the malignant phenotype. We have a particular interest in understanding the nature of the “cross-talk” between epithelial cancer cells and their stromal partners during cancer evolution. We bring together research scientists and clinicians to work on the research problems, with a focus always on the validation of ideas and observations in clinically-derived material, to ensure that bench-work is oriented toward understanding a “real” phenomenon.

Contact us

Centre Lead: Professor John Marshall

Deputy Centre Lead: Professor Richard Grose

Ground Floor, John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Recent Publications

  • Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment. Trends in Cancer (2019).
  • The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. J Pathol (2019) (2) PMID: 31259422
  • DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single- Molecule Control. ACS Nano (2019) 13(1):728-736. PMID: 30588806
  • Pancreatic Cancer Organotypic Models. Curr Top Microbiol Immunol (2019). PMID: 30790075
  • A new pragmatic design for dose escalation in phase 1 clinical trials using an adaptive continual reassessment method. BMC Cancer (2019) 19(2) 632. PMID: 31242873
  • Drosophila Genetics: Analysis of Tissue Growth in Adult Tissues. Methods Mol Biol 2(2019) 1893(2) 43-51. PMID: 30565123
  • The 100 000 Genomes Project: bringing whole genome sequencing to the NHS. BMJ (2018). PMID: 29691228

Latest News

  • Professor John Marshall was interviewed on Sky News on 12/02/2020 about his research, funded by the Pancreatic Cancer Research Fund, about using the foot-and-mouth-disease virus to help target pancreatic cancer. Read more here.
  • Antibody therapy extends survival in mice with pancreatic cancer - Scientists have found a way to target and knock out a single protein that they have discovered is widely involved in pancreatic cancer cell growth, survival and invasion. New study led by Professor John Marshall.
  • Pancreatic Cancer Research Fund supports two new vital research projects led by Professor Hemant Kocher and Dr Gunnel Halldén.
  • Congratulations to Professor Louise Jones who is the recipient of a Royal College of Pathologists (RCPath) Excellence Award.

Areas of focus

Translational tumour biology
SEM image of a cancer cell migrating down through a pore in a membrane
Tumour-stroma interactions
Periostin staining to highlight stroma in pancreatic cancer. (Source J Pathol 2019)
Breast cancer
Breast cancer cells. Credit: Anne Weston, Francis Crick Institute. CC BY-NC
Translational cancer metabolism
Multiclonal cancer cell line spheroid
Cell signalling
Inactive (left) and active (right) HER2-HER3 pairs - Credit: Phospho Biomedical Animation.
Pancreatic cancer
Pancreatic cancer cells. Credit: Anne Weston, Francis Crick Institute. CC BY-NC