Title: A Phase Ib/IIa study of AZD2014 in combination with Selumetinib in patients with advanced cancers
Disease site: Breast cancer
Status: Closed

Trial Design: Open-label, multicentre phase Ib/IIa study of AZD2014 (vistusertib) administered with selumetinib. There are two parts to this study: a dose-escalation part in treatment-refractory advanced solid tumours and a subsequent separate expansion cohort part for TNBC, squamous cell lung cancers, non-squamous cell lung cancers with KRAS mutations and non-squamous cell lung cancers with wild-type KRAS. The study will also assess the relationship between the anticipated anti-tumour activity of the treatment regimen and biological characteristics of patients’ tumour at baseline.

Trial details

Chief Investigator: Prof P. Schmid
Trial contact:
Clinical NCT02583542
EudraCT: 2014-002613-31
Sponsor: Queen Mary University of London
Participating countries: UK
Source of funding: Astra Zeneca UK Limited (funding and study drug)

Publications and presentations

A study of vistusertib in combination with selumetinib in patients with advanced cancers: TORCMEK phase Ib results. Peter Schmid, Martin David Forster, Yvonne J. Summers et al. Journal of Clinical Oncology (2017) 35:15_suppl, 2548-2548

Patient friendly information

Cancer Research UK website A trial looking at AZD2014 and selumetinib for advanced cancer (TORCMEK)

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