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Professor Hemant Kocher
Professor of Liver and Pancreas Surgery

My clinical research interests include tissue banking, clinical trials, innovative surgical techniques, epidemiology, meta-analysis and patient care pathways. My translational research interests include pancreatic cancer stroma and tumour-stroma cross-talk including cell signalling, adhesion, metastasis and invasion.

Professor Tyson V. Sharp
Professor of Cellular and Molecular Biology

My group’s work focuses on the role of the tumour suppressor protein LIMD1 and its family members Ajuba and WTIP and how their deregulation in normal tissue contributes to the development of lung, renal and breast cancer.

Dr Andrejs Braun
Senior Lecturer

I am interested in the mechanisms of tumour clearance in response to targeted therapy with monoclonal antibodies. I work on antibody therapies for lymphoma and the epigenetics of somatic hypermutation in normal and malignant B cells.

Dr Jeff Davies
Reader in Haemato-oncology and Honorary Consultant

My group works on developing novel approaches to improve efficacy and safety of allogeneic stem cell transplantation and adoptive immunotherapy as treatments for blood cancers. We focus on T-cell alloreactivity in the context of stem cell transplantation and immunotherapy.

Professor John Gribben
Professor of Medical Oncology

My group focuses on immunological approaches to the treatment of haematological cancers. My primary research interests include the immunotherapy of cancer (including stem cell transplantation), the identification of B-cell-tumour antigens; and the detection and treatment of minimal residual disease in leukaemia and lymphoma.

Dr Rifca Le Dieu
Clinical Senior Lecturer

I am the Module Lead for 3 undergraduate Biomedical Science Modules. I am also the Cancer Theme Lead for MBBS with direct responsibility for Year 2 Cancer Week. In addition, I supervise MSc project dissertations.

Dr Oliver M. Pearce
Lecturer

The focus of our research is the tumour microenvironment and we are particularly interested in understanding the composition and function of the tumour extracellular matrix in immunosuppression. Cancer types we focus on include ovarian and breast cancers.

Dr John Riches
Clinical Senior Lecturer

My major research interest is understanding the metabolism of chronic lymphocytic leukaemia and lymphoma with the aim that this will underpin the development of the next generation of anti-metabolic drugs for these diseases.

Professor Peter Szlosarek
Professor of Medical Oncology

My main research interest is in exploring why ASS1 is aberrantly expressed in human cancers and how this knowledge may be exploited for anticancer therapy. I lead an active translational programme from bench to bedside of the arginine-depleting agent ADI-PEG20 in several hard-to-treat cancers.

Professor Yaohe Wang
Professor of Cancer Cell and Gene Therapy

We work on cancer prevention and immunotherapy using tumour-targeted replicating oncolytic viruses, in particular focusing on replicating adenovirus and vaccinia virus.

Dr Ann-Marie Baker

I am interested in understanding tumour evolution and stem cell biology within the human colon.

Dr Renato Brito Baleeiro

The primary focus of my research is to establish a platform for a neo-antigens-based vaccine for triple-negative breast cancer and pancreatic cancer.

Dr Louisa Chard

Our research focuses on the use of modified, replicating oncolytic Vaccinia viruses and adenoviruses armed with immune-modulatory genes such as cytokines to create a self-propagating treatment for tumours that results in long-term immunological memory to the tumour cells.

Dr Suhnrita Chaudhuri

My research is focused on combining modulation of the tumour microenvironment with chimeric antigen receptor T cell therapy in order to therapeutically target pancreatic ductal adenocarcinoma.

Dr Marta Crespi-Sallan

My research is focused on describing the mechanisms underlying Lamin B1 nuclear disassembly in B-cell normal development and how a dis-regulated Lamin B1 removal pathway could lead to several haematological malignancies within the germinal centre in secondary lymph organs.

Dr Danilo Cucchi

My main research is focused on the identification of DNA damage signatures that predict response to immune checkpoint blockade. I am also interested in the role of metabolism in the biology of both cancer cells and immune cells.

Dr Daniel Friedman

My research is focused on investigating the crosstalk between immune cell subsets in the tumour microenvironment in pancreatic ductal adenocarcinoma.

Dr Ganga Gopinathan

My research project aims to investigate the inflammatory cytokine IL-6 as a major target in high grade serous carcinoma, with the hope of identifying targeted therapies for treatment.

Dr Florian Laforets

My research in Prof Balkwill’s group focuses on imaging tumour-associated macrophages and other immune cells in live ex vivo tumour slices, in order to assess their behaviour and the impact of immunotherapies on the live tumour microenvironment.

Dr Eszter Lakatos

I apply bioinformatic techniques and mathematical modelling to understand the evolutionary processes in colorectal cancer. My research focuses on the trade-offs a growing tumour population has to face for efficient growth and survival.

Dr Peng Liu

I am interested in cancer prevention and immunotherapy using tumour-targeted replicating oncolytic viruses.

Dr Oscar Maiques

My research will focus on studying Myosin II function during melanoma progression and its cross-talk with inflammatory and immune responses.

Dr Eleni Maniati

My research project aims to integrate multi-omic molecular and histological data datasets of the microenvironment of HGSOC metastases. This work will allow us to identify key microenvironmental components and pathways that sustain and promote tumours.

Dr Giulia Marelli

I am investigating the use of virotherapeutic strategies for treating pancreatic cancer. Our research focuses on the use of modified oncolytic Vaccinia viruses armed with immune-modulatory genes such as cytokines to create a novel treatment for tumours.

Dr Shinelle G. Menezes

My work focuses on the influence of PKN2 on the immune-microenvironment, and the invasion and metastasis of pancreatic ductal adenocarcinoma in vivo, using murine models.

Dr Judith Simon

Our study aims to investigate the role of centrosome amplification on changing the tumour microenviroment using in vitro and in vivo models.

Dr Filomena Spada

My research involves using mass cytometry based analysis to characterise the interaction, activation, and signalling capacity of B and T-cells in CLL and other B-cell malignancies.

Dr Ming Yuan

My research focus is on cancer immunotherapy using oncolytic viruses (vaccinia virus) and engineered T cells.