I am interested in all the strategies cancer cells adopt to proliferate and evade cell death, in order to develop new therapeutic strategies. Specifically, my research focuses on how cancer cell metabolism affects tumour growth and investigating how inflammation can drive malignant transformation.
My lab aims to understand the alterations in metabolism that take place in cancer and investigate whether extrinsic factors, such as diet, influence cancer metabolism and disease trajectory. We then want to uncover whether these dependencies can be exploited therapeutically.
My main research interest is in exploring why ASS1 is aberrantly expressed in human cancers and how this knowledge may be exploited for anticancer therapy. I lead an active translational programme from bench to bedside of the arginine-depleting agent ADI-PEG20 in several hard-to-treat cancers.
We are investigating the metabolic dependencies of cancer cells under biologically relevant conditions, such as nutrient stress, in a biomarker-specific manner. I use metabolomics, proteomics and other cutting-edge platforms to dissect the metabolic architecture of cancer models that harbour alterations in tumour suppressors that drive disease trajectory and treatment response.