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Professor Fran Balkwill
Professor of Cancer Biology

My key area of interest is in cancer and the tumour microenvironment, especially in ovarian cancer. I study the links between cancer and inflammation and research ways of translating this to clinical trials.

Professor Kairbaan Hodivala-Dilke
Deputy Institute Director, Professor of the Tumour Microenvironment

Cancers are composed of both tumour and stromal compartments. We are interested in understanding the molecular basis of how the tumour stroma contributes to tumour growth, therapy resistance and spread, in various solid tumours including lung cancers, pancreatic cancer and melanoma.

Professor Hemant Kocher
Professor of Liver and Pancreas Surgery

My clinical research interests include tissue banking, clinical trials, innovative surgical techniques, epidemiology, meta-analysis and patient care pathways. My translational research interests include pancreatic cancer stroma and tumour-stroma cross-talk including cell signalling, adhesion, metastasis and invasion.

Dr Angus James Cameron
Senior Lecturer

My research focuses on kinases regulating cancer cell growth and motility to understand how and when to target them with drugs. My group is currently examining the role of the PKN kinases in malignant progression.

Dr Mirjana Efremova
Lecturer

We are interested in understanding the cellular and molecular mechanisms that promote cancer cell plasticity and adaptation of tumour cells in metastatic niches and under therapeutic pressure.

Dr Miguel Ganuza
Lecturer

Our goal is to identify mechanisms that support haematopoietic stem cell function and understand how the leukaemic stem cells “play” with these mechanisms to thrive.

Dr Li Jia
Senior Lecturer

I am interested in studying the effects of the inflammatory microenvironment on disease progression and resistance to treatment in haematological malignancies with emphasis on survival and mechanisms of treatment resistance in chronic lymphocytic leukaemia and B cell lymphoma.

Dr Ioanna Keklikoglou
Lecturer

Our group focuses on understanding the molecular and cellular mechanisms that mediate resistance to anti-cancer therapies in breast cancer. We are interested in dissecting the microenvironmental cues that orchestrate specific tumour responses and metastasis formation.

Dr Luigi Ombrato
Lecturer

My group studies how different populations of immune cells in the tumour microenvironment cross-talk in order to establish a “favourable” niche in metastasis.

Dr Oliver M. Pearce
Lecturer

The focus of our research is the tumour microenvironment and we are particularly interested in understanding the composition and function of the tumour extracellular matrix in immunosuppression. Cancer types we focus on include ovarian and breast cancers.

Dr Barrie Peck
Lecturer

My lab aims to understand the alterations in metabolism that take place in cancer and investigate whether extrinsic factors, such as diet, influence cancer metabolism and disease trajectory. We then want to uncover whether these dependencies can be exploited therapeutically.

Professor Victoria Sanz-Moreno
Professor of Cancer Cell Biology

Our research focuses on how the cytoskeleton of cancer cells regulates transcriptional rewiring during tumour growth and dissemination. We aim to understand how such rewiring affects the tumour microenvironment.

Dr Sam Burgess

My research is primarily focused on exploring how the bone marrow niche regulates haematopoietic stem cell development and leukaemia progression.

Dr Michelle Goulart

My research is focused in understanding the tumour-stroma interactions in pancreatic cancer and the identification of potential biomarkers.

Dr Paul Grevitt

My research projects involve identifying tumour suppressors involved in regulating the hypoxic response and metabolic stress, with the aim to identify novel targeted therapies against these.

Dr Anastasia Kapara

We are investigating the metabolic dependencies of cancer cells under biologically relevant conditions, such as nutrient stress, in a biomarker-specific manner. I use metabolomics, proteomics and other cutting-edge platforms to dissect the metabolic architecture of cancer models that harbour alterations in tumour suppressors that drive disease trajectory and treatment response.

Dr Panoraia Kotantaki

My research is focused on the tumour microenvironment of ovarian cancer with a particular focus on the extracellular matrix and how current and novel treatments influence this microenvironment.

Dr Beatrice Malacrida

My research focuses on designing 3D in vitro models to understand the contribution of the tumour microenvironment during HGSOC progression.

Emma Newport

I am working to produce a bank of pancreatic cancer organoids from KPC mice. We hope to use these to model PDAC in vivo and in vitro.

Dr Sam Ogden

We are using single cell multi-omic approaches to study how cancer cell plasticity and the tumour microenvironment contribute to metastasis in colorectal cancer.

Dr Elly Tyler

My research investigates a specific composition of extracellular matrix molecules which may explain the difference between responders and non-responders to immunotherapy.

Dr Laura Wisniewski

My project looks at the modelling of cancer for improved therapy development. I am carrying out in vivo cancer experiments, with and without modifications of the tumour microenvironment, to examine effects of such treatments on anti-cancer therapy efficacy.