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Professor Fran Balkwill
Professor of Cancer Biology

My research is focused on the links between cancer and inflammation, being especially interested in translating knowledge of cancer biology into new biological treatments for cancer and in the role that inflammatory cytokines play in cancer promotion. We study the tumour microenvironment of ovarian cancer using a platform of human multi-cellular tissue culture models and mouse models to research biological therapies that may prevent relapse and increase patient survival.

Professor Kairbaan Hodivala-Dilke
Deputy Institute Director, Professor of the Tumour Microenvironment

Our research aims to improve the efficacy of standard of care immunotherapy, chemotherapy and radiotherapy in human solid cancers by understanding the molecular mechanisms underlying tumour stromal contributions to tumour growth and therapy efficacy.

Professor Hemant Kocher
Professor of Liver and Pancreas Surgery

My clinical research interests include tissue banking, clinical trials, innovative surgical techniques, epidemiology, meta-analysis and patient care pathways. My translational research interests include pancreatic cancer stroma and tumour-stroma cross-talk including cell signalling, adhesion, metastasis and invasion.

Dr Angus James Cameron
Senior Lecturer

My research focuses on kinases regulating cancer cell growth and motility to understand how and when to target them with drugs. My group is currently examining the role of the PKN kinases in malignant progression.

Dr Mirjana Efremova
Lecturer

We are interested in understanding the cellular and molecular mechanisms that promote cancer cell plasticity and adaptation of tumour cells in metastatic niches and under therapeutic pressure.

Dr Paolo Gallipoli
Clinical Reader in Experimental Haematology

My research interests focus on mechanisms of disease initiation and maintenance and the identification and validation of novel therapeutic targets in myeloid leukaemias.

Dr Miguel Ganuza
Senior Lecturer

Our goal is to identify mechanisms that support haematopoietic stem cell function and understand how the leukaemic stem cells “play” with these mechanisms to thrive.

Dr Ioanna Keklikoglou
Lecturer

Our group focuses on understanding the molecular and cellular mechanisms that mediate resistance to anti-cancer therapies in breast cancer. We are interested in dissecting the microenvironmental cues that orchestrate specific tumour responses and metastasis formation.

Dr Luigi Ombrato
Lecturer

My group studies how different populations of immune cells in the tumour microenvironment cross-talk in order to establish a tumour-supportive niche in metastasis. This research aims to identify more effective therapeutic targets in metastatic cancers.

Dr Oliver M. Pearce
Lecturer

The focus of our research is the tumour microenvironment and we are particularly interested in understanding the composition and function of the tumour extracellular matrix in immunosuppression. Cancer types we focus on include ovarian and breast cancers.

Dr Barrie Peck
Lecturer

My lab aims to understand the alterations in metabolism that take place in cancer and investigate whether extrinsic factors, such as diet, influence cancer metabolism and disease trajectory. We then want to uncover whether these dependencies can be exploited therapeutically.

Professor Victoria Sanz-Moreno
Professor of Cancer Cell Biology

Our research focuses on how the cytoskeleton of cancer cells regulates transcriptional rewiring during tumour growth and dissemination. We aim to understand how such rewiring affects the tumour microenvironment.

Dr Lourdes Chulia-Peris

My research focuses on studying the bidirectional crosstalk between normal fibroblast (NF), CAFs, matrix organisation and the acquisition of tumour amoeboid cell state in co-culture systems.

Dr Maria Fankhaenel

My research focuses on understanding how centrosome amplification impacts tumour angiogenesis and how this can be targeted to develop new cancer therapies.

Dr Paul Grevitt

My research projects involve identifying tumour suppressors involved in regulating the hypoxic response and metabolic stress, with the aim to identify novel targeted therapies against these.

Dr Joash Joy

My research focuses on building human tumour models within microfluidic chips that recapitulate features of the tumour microenvironment, such as blood vessels.

Dr Katarina Kluckova

We are interested in metabolic dependencies of B-cell lymphomas, in particular the serine synthesis pathway and one carbon metabolism.

Dr Panoraia Kotantaki

My research is focused on the tumour microenvironment of ovarian cancer with a particular focus on the extracellular matrix and how current and novel treatments influence this microenvironment.

Dr Paramita Kundu

My project aims to explore the contribution of nuclear-cytoplasmic distribution and traffic of transcription factors that aid the aggressiveness of melanoma, and explore possible epigenetic aspects of melanoma initiation and progression.

Dr Meng-Lay Lin

My research interest focuses on risk stratification signatures for Barrett’s oesophagus progression to cancer using high throughput multiplexed imaging, bioinformatics, shallow whole genome sequencing, and spatial transcriptomics.

Dr Beatrice Malacrida

My research focuses on designing 3D in vitro models to understand the contribution of the tumour microenvironment during HGSOC progression.

Dr Juan Manuel Marti

My current project dissects the role that the protein FAK plays on the induction of senescence observed in endothelial cells (ECs) after DNA damage therapy, and its role in lung cancer metastasis.

Dr Sam Ogden

We are using single cell multi-omic approaches to study how cancer cell plasticity and the tumour microenvironment contribute to metastasis in colorectal cancer.

Dr Elly Tyler

My research investigates a specific composition of extracellular matrix molecules which may explain the difference between responders and non-responders to immunotherapy.

Dr Laura Wisniewski

My project looks at the modelling of cancer for improved therapy development. I am carrying out in vivo cancer experiments, with and without modifications of the tumour microenvironment, to examine effects of such treatments on anti-cancer therapy efficacy.