Dr Li Jia

MB, PhD
Senior Lecturer
Group Leader
Research Focus

I am interested in studying the effects of the inflammatory microenvironment on disease progression and resistance to treatment in haematological malignancies with emphasis on survival and mechanisms of treatment resistance in chronic lymphocytic leukaemia and B cell lymphoma.

Key Publications

CD126 and targeted therapy with Tocilizumab in Chronic Lymphocytic Leukemia. Clin Cancer Res (2016) 15;22(10):2462-9. PMID: 26712690

Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma. Oncotarget (2015) 29;6(29):27816-31. PMID: 26315113

Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2. Oncotarget (2014) 5(22):11653-68. PMID: 25362242

Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia. Blood (2014) 123(11):1709-19. PMID: 24464016

Major Funding
  • 2015-2016- Kay Kendall Leukaemia Fund, Identification of HMGB12 as a novel therapeutic target for the treatment of chronic lymphocytic leukaemia, £136,831
  • 2016-2019: National Natural Science Foundation, China
Other Activities
  • Editorial Board: Chinese Journal of Clinical Oncology
  • Honorary Professor in Tianjin Medical University Cancer Institute and Hospital, China
Research

For over 20 years, my main research work focused on overcoming the resistance of leukaemia and lymphoma cells to chemo- or immuno-therapy, and the roles of mitochondria and BCL-2 family proteins in apoptotic cell death.

Our studies now focus on the impact of the inflammatory microenvironment on survival and treatment resistance mechanisms of chronic lymphocytic leukaemia (CLL) and B cell lymphoma.

Current research focuses are:

  • The roles of inflammatory microenvironment on CLL cell survival and resistance to novel anti-cancer drugs;
  • The impact of soluble inflammatory factors and their receptors on prognosis and clinical outcomes for patients with CLL;
  • Soluble inflammatory factor-mediated intracellular signalling network in malignant B-cells.
Other Activities
  • Editorial Board: Chinese Journal of Clinical Oncology
  • Honorary Professor in Tianjin Medical University Cancer Institute and Hospital, China
Major Funding
  • 2015-2016- Kay Kendall Leukaemia Fund, Identification of HMGB12 as a novel therapeutic target for the treatment of chronic lymphocytic leukaemia, £136,831
  • 2016-2019: National Natural Science Foundation, China
Recent Publications

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For additional publications, please click here
Team

PhD Students
Ms Arantxa Romero Toledo

Biography

Education and Qualifications

  • 1994-1997: PhD in Cell Biology of Haematology. Department of Haematology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry.
  • 1984-1985: Diploma in Advanced Biochemistry. NanKai University, Tianjin, China.
  • 1978-1983: Medical Bachelor (MB). China Medical University, Shenyang, China.

Career progression

  • Since Sept. 2008: Senior Lecturer. Centre for Haematological Oncology, Barts Cancer Institute, Queen Mary University of London.
  • Oct 2004-Aug 2008: Senior Lecturer. Centre for Haematology, Institute of Cell and Molecular Science.
    July 2000: Non-Clinical Lecturer and leader of the apoptosis laboratory. Centre for Haematology, Institute of Cell and Molecular Science.
  • 1997-1999: Post-doctoral Research Fellow. Department of Haematology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry. Supported by Leukaemia Research Fund.
  • 1994-1996: Research Assistant and PhD student. Department of Haematology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry.
  • 1989-1993: Associate Researcher Department of Biochemistry and Molecular Biology, Institute of Haematology and Blood Disease Hospital, Chinese Academy of Medical Sciences. P.R. China.
  • 1983-1989: Research Assistant. Department of Biochemistry and Molecular Biology, Institute of Haematology and Blood Disease Hospital, Chinese Academy of Medical Sciences.