My research is focused on the links between cancer and inflammation, being especially interested in translating knowledge of cancer biology into new biological treatments for cancer and in the role that inflammatory cytokines play in cancer promotion.
Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers. Cancer Discov (2018) 8(3):304-319. PMID: 29196464
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer. J Clin Invest (2017) 127(3):801-813. PMID: 28134623
A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases. Clin Cancer Res (2016) 23(1):250-262. PMID: 27354470
Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma. Clinical Cancer Research (2016) 22(12):3025-36. PMID: 27306793
I am Professor of Cancer Biology at Barts Cancer Institute, Queen Mary University of London, where I lead the Centre for Cancer and Inflammation and the Cytokine and Cancer group within that Centre. I study the links between cancer and inflammation and research ways of translating this to clinical trial.
My key research areas of interest are:
Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment Maniati E, Berlato C, Gopinathan G et al. Cell Reports (2020) 30(7) 525-540.e7
Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours Marques P, Barry S, Carlsen E et al. Acta neuropathologica communications (2019) 7(7) 172
Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference Bast RC, Matulonis UA, Sood AK et al. Cancer (2019) 125(1) 1963-1972
Discrepancies in the tumor microenvironment of spontaneous and orthotopic murine models of pancreatic cancer uncover a new immunostimulatory phenotype for B cells Spear S, Candido JB, McDermott JR et al. Frontiers in Immunology (2019) 10(1)
Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness Marques P, Barry S, Carlsen E et al. Endocrine-Related Cancer (2019) 26(7) 853-865
Mets and NETs: The Awakening Force Sanz-Moreno V, Balkwill FR Immunity (2018) 49(1) 798-800
CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype Candido JB, Morton JP, Bailey P et al. Cell Reports (2018) 23(7) 1448-1460
Cytokines Malik STA, Balkwill FR (2018) (7) 247-261
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Pearce OMT, Delaine-Smith R, Maniati E et al. Cancer Discov (2017) (1)
The Chemokine CXCL10 is a Potential Regulator of Cancer Stem Cells in High Grade Serous Carcinoma McDermott JR, Jones R, Lockley M et al. JOURNAL OF PATHOLOGY (2017) 243(11) S15-S15
Clinical Research Fellows
Dr Owen Heath
Priyankaa Goordyal, Joash Joy, Laura Lecker
In 2006, I was made a Fellow of the Academy of Medical Sciences, being elected a member of its Council later in the same year. I am a frequent plenary and keynote speaker at international meetings, such as Gordon and Keystone conferences and the American Association for Cancer Research (AACR).
I am also actively involved in communication of science to non-specialist audiences, especially young people. I have written thirteen science books for children on cell and molecular biology, with titles such as Enjoy Your Cells and The Egg and Sperm Race.
I am the Director of the Centre of the Cell, a biomedical science centre for children, educational website, and widening participation and outreach project in Whitechapel. The website was launched in March 2007 and the physical Centre opened in September 2009. As of July 2017 there have been over 171,000 participants in Centre of the Cell activities (www.centreofthecell.org).
I am a non-parliamentary board member of the Parliamentary Office of Science and Technology, POST and a Trustee of Bloodwise. I was awarded an OBE in the 2008 Queen's Birthday Honours list. In 2015 I was made a Doctor of Science honoris causa by the University of Bristol and in 2017 was awarded the Cancer Research UK Inspiring Leadership in Research Engagement Prize.