Research

I am currently Chairman of the International Breast Cancer Intervention Study (IBIS) Steering Group and the ATAC trial. I have worked extensively in breast cancer and was the first to report the effect of tamoxifen on contralateral tumours as an indicator of its potential chemopreventive role. I demonstrated that a change in mammographic breast density on endocrine treatment is a biomarker for its effectiveness.

I am involved in studies on the use of HPV assays for cervical screening, the use of flexible sigmoidoscopy for colorectal cancer screening and markers for the behaviour of early prostate cancer.

I am the statistician for several major breast cancer trials and maintain an active interest in developing new statistical methodology, especially in the area of adjustments for non-compliance and cross-over, and multi-arm clinical trials.

Other Activities

• Fellow of the Academy of Medical Sciences
• Fellow of the Royal Society
• Science Strategy Committee member for Breast Cancer Now
• Research Strategy Group member for Prostate Cancer UK

Major Funding

• 2018-2023- CRUK, Catalyst
• 2017-2020- Barts Charity, Preventative Neurology
• 2014-2019- CRUK, Cancer Prevention
• 2007-2019- CRUK, IBIS II

Recent Publications

Obesity at age 20 and weight gain during adulthood increase risk of total and premature all-cause mortality: findings from women attending breast screening in Manchester Pegington M, Harvie M, Harkness EF et al. BMC Women's Health (2023) 23(7)

Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent Roberts E, van Veen EM, Byers H et al. Genetics in Medicine (2023) 25(7)

Impact of HPV testing in opportunistic cervical screening: Support for primary HPV screening in the United States Cuzick J, Adcock R, Kinney W et al. International Journal of Cancer (2023) 153(7) 83-93

Correction To: Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420) (British Journal of Cancer, (2023), 128, 11, (2063-2071), 10.1038/s41416-023-02250-w) Gareth Evans D, McWilliams L, Astley S et al. British Journal of Cancer (2023) 128(7) 2140

Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420) Gareth Evans D, McWilliams L, Astley S et al. British Journal of Cancer (2023) 128(7) 2063-2071

Evaluation of an AI Model to Assess Future Breast Cancer Risk Damiani C, Kalliatakis G, Sreenivas M et al. Radiology (2023) 307(7)

Measuring cancer burden in prostatic needle core biopsies: simplified assessments outperform complex measurements in assessing outcome: evidence to assist pathologist efficiency and minimize datasets Berney DM, Finnegan K, Chu K et al. Histopathology (2023) 82(7) 1021-1028

Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100 000 women from 86 randomised trials. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Electronic address: bc.overview@ctsu.ox, Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) Lancet (2023) 401(2) 1277-1292
https://www.ncbi.nlm.nih.gov/pubmed/37061269

GPs’ willingness to prescribe aspirin for cancer preventive therapy in Lynch syndrome: a factorial randomised trial investigating factors influencing decisions Lloyd KE, Hall LH, Ziegler L et al. British Journal of General Practice (2023) 73(7) E302-E309

P240 Computerized Quantification of Tumor Infiltrating Lymphocyte (TIL) as a prognostic and predictive factor in ductal carcinoma in situ: Results from the UK/ANZ DCIS randomized trial Li H, Madabhushi A, Badve S et al. The Breast (2023) 68(10) s111

Biography

I received my BSc in Mathematics and Physics from Harvey Mudd College, Claremont, California. I then studied an MSc in Mathematics at the University of London. I obtained my PhD in Mathematics from Claremont Graduate School, Claremont, California.

I was appointed John Snow Professor of Epidemiology at Queen Mary University of London. In 2017, I was awarded a CRUK Lifetime Achievement Award and a CBE.