My lab measures the patterns of clonal evolution that define carcinogenesis and develops novel mathematical tools for analysis and prediction. By characterising tumour evolution, we aim to find better ways to determine prognosis and more effective ways to treat cancers.
Quantification of subclonal selection in cancer from bulk sequencing data. Williams MJ, Werner B, Curtis C, Barnes C*, Sottoriva A*, Graham TA*. Nature Genetics (2018) 50(6) 895-903. PMID: 29808029
Identification of neutral tumor evolution across cancer types. Williams M, Werner B, Barnes C, Graham TA*, Sottoriva A*. Nature Genetics (2016) 44, 238-244. PMID: 26780609
The effects of mutational processes and selection on driver mutations across cancer types. Temko D, Tomlinson IPM, Severini S, Schuster-Bockler B*, Graham TA*. Nature Communications (2018) 9(1) 1857. PMID: 29748584
Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution. Baker AM, Huang W, Wang XMM, Jansen M, Ma XJ, Kim J, Anderson CM, Wu X, Pan L, Su N, Luo Y, Domingo E, Heide T, Sottoriva A, Lewis A, Beggs AD, Wright NA, Rodriguez-Justo M, Park R, Tomlinson IPM*, Graham TA*. Nature Communications (2017), 8(1) 1998. PMID: 29222441
The central themes of my lab are:
The major tools of the lab are genomics, bioinformatics, histopathology and mathematical modelling.
Resolving genetic heterogeneity in cancer. Turajlic S, Sottoriva A, Graham T et al. Nat Rev Genet (2019) 20(1) 404-416
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data. Chkhaidze K, Heide T, Werner B et al. PLoS Comput Biol (2019) 15(2) e1007243
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios Williams M, Zapata L, Werner B et al. (2019) (18)
Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Araf S, Wang J, Korfi K et al. Leukemia (2019) 33(2) 1540
Evolutionary history of human colitis-associated colorectal cancer. Baker A-M, Cross W, Curtius K et al. Gut (2019) 68(2) 985-995
Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapy. Heide T, Maurer A, Eipel M et al. J Pathol (2019) 248(2) 230-242
NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline. Schenck RO, Lakatos E, Gatenbee C et al. BMC Bioinformatics (2019) 20(2) 264
Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. Baker A-M, Cereser B, Melton S et al. Cell Rep (2019) 27(1) 2524-2524
Measuring Clonal Evolution in Cancer with Genomics. Williams MJ, Sottoriva A, Graham TA Annu Rev Genomics Hum Genet (2019) (1)
Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer Gatenbee C, Baker A-M, Schenck R et al. (2019) (18)For additional publications, please click here
I originally trained as a mathematician (MSci Mathematics, Imperial College, 2002) before spending time in a cancer genetics lab as part of my interdisciplinary PhD (PhD Mathematical Biology, UCL, 2009). As a postdoc, I worked in Nick Wright's lab at the Cancer Research UK London Research Institute studying clonal expansions in human tissues (2008-2011), and Carlo Maley’s lab at UCSF looking at the pattern of clonal evolution in human cancers (2011-2013).
I joined BCI in September 2013.
Please contact me to discuss opportunities. Further information about my lab can be found here.