Tag: Microenvironment
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Mapping the emergence of treatment resistance in leukaemia
28th September 2021
Research led by Barts Cancer Institute, Queen Mary University of London, has identified a new role for a group of cells called adipocytes in contributing to treatment resistance in a type of leukaemia. Published in Nature Communications, the findings broaden the understanding of resistance pathways in blood cancer cells, which is critical for developing novel treatment strategies to improve outcomes for people with leukaemia.
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Immune cells assemble – boosting the effects of chemotherapy in pancreatic cancer
9th July 2021
A new study from Barts Cancer Institute, Queen Mary University of London, has demonstrated that immune cells can be stimulated to assemble into special structures within pancreatic cancer such that, at least in a pre-clinical model, researchers can demonstrate an improvement in the efficacy of chemotherapy.
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Building a human tumour microenvironment in the lab
15th June 2021
Researchers from Barts Cancer Institute at Queen Mary University of London, led by Professor Fran Balkwill and Dr Oliver Pearce, have built two 3D multi-cellular models of the human tumour microenvironment (TME) in ovarian cancer. The models, which are the first created from the CanBuild project, have revealed novel insights into the role of the TME in cancer progression.
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Impact of chemotherapy on immune cells in the TME
10th April 2021
Research from Barts Cancer Institute, Queen Mary University of London, has revealed novel insights into the effects of chemotherapy on the tumour microenvironment (TME). The study found that chemotherapy enhances the anti-tumour actions of immune cells within the TME and their ability to support immune responses against cancer.
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Blood vessel protein has protective role in cancer
4th June 2020
A study has identified a novel mechanism that controls tumour growth, involving a particular protein expressed by specialised cells within tumour blood vessels.
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Pericytes and control of cancer growth
29th May 2020
New study reveals novel insights into the role of blood vessels within the tumour microenvironment in the regulation of cancer growth. Understanding this relationship better may provide new avenues that can be explored for cancer therapies.
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