PhD Studentship: The role of long noncoding RNAs in cell division and genome stability

Application deadline: 15/11/2019

Start date: 02/01/2020

A graduate with an interest in RNA and cell biology, with or is expecting at least an upper second class honours degree in a relevant biological/biochemical subject, is required for this project involving investigating the role of long noncoding RNAs in the control of cell division and maintenance of genome stability. An MSc/MRes, or laboratory experience, in a relevant area may well prove advantageous. The project will commence in January 2020 and has funding for 3 years from Barts Charity. The student will be based primarily at the Barts Cancer Institute, Barts and the London School of Medicine and Dentistry (SMD), Charterhouse Square in the City of London.

Primary Supervisor: Dr Lovorka Stojic
Centre for Cancer Cell and Molecular Biology
Project description

Our group studies the biology of long noncoding RNAs (lncRNAs) and their roles in cell division and maintenance of genome stability. With the RNAi imaging screen, we have identified novel lncRNAs involved in regulation of cell division whose expression is altered in different types of cancer. In this project we will i) functionally dissect specific lncRNA genes involved in cell division, ii) identify lncRNA molecular interactors, and iii) determine their functional relevance in pathways governing genome stability. To that end, we are combining functional cell biology, imaging, genomics and proteomics approaches in human cells to elucidate the importance of lncRNAs in the control of cell division. Our ultimate goal is to understand how dysregulation of lncRNA-mediated regulatory networks contribute to genome instability in cancer. For more information about the group, please visit stojiclab.com.

Who should apply?

Academic Entry Requirements

These studentships are open to graduates with

  • a 2:1 or 1st degree in a related subject, with experience of cell/molecular biology

English Language Requirements

Applicants for whom English is not a first language will also require a minimum IELTS score of 6.5 (with 6.0 in the written component) or equivalent, unless your undergraduate degree was studied in, and awarded by, an English speaking country. For more information on acceptable English language qualifications please see here.

Fee Status

The funding for this studentship only covers tuition fees at the home/EU rate. Overseas applicants are welcome to apply, but will be required to fund the difference in tuition fees.

Funding

The studentship includes the following funding for 3 years:

  • A tax-free annual stipend of £21,000
  • Tuition fees at the Home/EU rate*
  • Project consumables

*If you are considered an overseas student for fee purposes, you are welcome to apply for this studentship, however you will be required to cover the difference in tuition fees.

How to apply

To apply you will need to complete an online application form.

The following supporting documents will be required as part of your application:

  • Your CV
  • Statement of purpose
  • Details of 2 referees
  • Copy of your transcript(s), including a breakdown of marks
  • Copy of your passport
  • If applicable, proof of English proficiency
Who to contact if you require further information

If you have a question about the project, or would like to arrange an informal discussion, please contact the supervisor directly (subject ‘PhD applicant’). For general enquiries about the PhD studentship or application process please contact bci-cancercourses@qmul.ac.uk 

What are the next steps in the application process?

Successfully shortlisted candidates will be invited to an interview at Barts Cancer Institute.