Peter Schmid, Javier Cortes, Rebecca Dent, Lajos Pusztai, Heather McArthur, Sherko Kümmel, Jonas Bergh, Carsten Denkert, Yeon Hee Park, Rina Hui, Nadia Harbeck, Masato Takahashi, Michael Untch, Peter A Fasching, Fatima Cardoso, Jay Andersen, Debra Patt, Michael Danso, Marta Ferreira, Marie-Ange Mouret-Reynier, Seock-Ah Im, Jin-Hee Ahn, Maria Gion, Sally Baron-Hay, Jean-François Boileau, Yu Ding, Konstantinos Tryfonidis, Gursel Aktan, Vassiliki Karantza, Joyce O'Shaughnessy, KEYNOTE-522 Investigators
N Engl J Med. 2022 Feb 10;386(6):556-567. doi: 10.1056/NEJMoa2112651.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
Winners: Liz Murray, Shinelle Menezes & Angus Cameron
Cell Rep. 2022 Jan 25;38(4):110227. doi: 10.1016/j.celrep.2021.110227.
Winner: Thomas Powles
Nat Med. 2021 Dec;27(12):2200-2211. doi: 10.1038/s41591-021-01579-0. Epub 2021 Dec 10.
Winner: Stephen Duffy
Lancet Reg Health Eur. 2021 Sep 11;10:100179. doi: 10.1016/j.lanepe.2021.100179. eCollection 2021 Nov.
Winners: Hannah Lawson & Kamil Kranc
Stem Cell Reports. 2021 Nov 9;16(11):2784-2797. doi: 10.1016/j.stemcr.2021.10.001. Epub 2021 Oct 28.
Winners: Quentin Heydt & Bela Wrench
Nat Commun. 2021 Sep 17;12(1):5507. doi: 10.1038/s41467-021-25540-4.
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
Winners: Oscar Maiques & Eva Crosas-Molist
Br J Cancer. 2021 Aug;125(5):699-713. doi: 10.1038/s41416-021-01442-6. Epub 2021 Jun 25.
Winner: Peter Schmid
Ann Oncol. 2021 Aug;32(8):983-993. doi: 10.1016/j.annonc.2021.05.355. Epub 2021 Jul 1.
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma
Winner: Tom Powles
Nature. 2021 Jul;595(7867):432-437. doi: 10.1038/s41586-021-03642-9. Epub 2021 Jun 16.
Winner: Tom Powles
Nat Med. 2021 May;27(5):793-801. doi: 10.1038/s41591-021-01317-6. Epub 2021 May 3.
Winner: Owen Heath & Fran Balkwill
Cancer Immunol Res. 2021 Apr 10;canimm.0968.2020. doi: 10.1158/2326-6066.CIR-20-0968. Online ahead of print.
Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs
Winner: Henry Gerdes, Pedro Casado, Arran Dokal, Maruan Hijazi & Pedro Cutillas
Nat Commun. 2021 Mar 25;12(1):1850. doi: 10.1038/s41467-021-22170-8.
Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
Winner: Sophie Adams & Susana Godinho
Curr Biol. 2021 Feb 9;S0960-9822(21)00061-0. doi: 10.1016/j.cub.2021.01.028. Online ahead of print.
CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma
Winner: Deepak Raj and John Marshall
Clin Cancer Res. 2021 Jan 21. doi: 10.1158/1078-0432.CCR-19-2163. Online ahead of print.
Winner: Silvana Debernardi and Tatjana Crnogorac-Jurcevic
PLoS Med. 2020 Dec 10;17(12):e1003489. doi: 10.1371/journal.pmed.1003489. eCollection 2020 Dec.
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells
Winner: Maria Dermit & Faraz Mardakheh
Dev Cell. 2020 Nov 9;55(3):298-313.e10. doi: 10.1016/j.devcel.2020.10.006.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
Winner: Irene Rodriguez-Hernandez and Victoria Sanz-Moreno
Nat Commun. 2020 Oct 20;11(1):5315. doi: 10.1038/s41467-020-18951-2.
Evolutionary dynamics of neoantigens in growing tumors
Winner: Eszter Lakatos & Trevor Graham
Nat Genet. (2020) Oct;52(10):1057-1066. doi: 10.1038/s41588-020-0687-1. Epub 2020 Sep 14.
Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma
Winner: Thomas Powles
N Engl J Med. (2020) Sep 24;383(13):1218-1230. doi: 10.1056/NEJMoa2002788. Epub 2020 Sep 18.
This paper also won Paper of the Year 2020
Winner: Stephen Duffy & Sue Moss
Lancet Oncol. (2020) Aug 12;S1470-2045(20)30398-3. doi: 10.1016/S1470-2045(20)30398-3. Online ahead of print.
Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
Winner: Hemalvi Patani & Gabriela Ficz
Nat Commun 11, 3671 (2020). https://doi.org/10.1038/s41467-020-17269-3
Winner: Stephanie Kermorgant
Sci Signal (2020) 13(637):eaba8627. doi: 10.1126/scisignal.aba8627.
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk With Tumor Cells
Winner: Ping-Pui Wong, José M Muñoz-Félix & Kairbaan Hodivala-Dilke
Cell (2020) May 28;S0092-8674(20)30147-1. doi: 10.1016/j.cell.2020.02.003. Online ahead of print.
This paper also won Paper of the Year 2020
Winner: Adam Brentnall
Int J Cancer. 2020 Apr 15;146(8):2122-2129. doi: 10.1002/ijc.32541. Epub 2019 Jul 13.
Cancer associated fibroblast FAK regulates malignant cell metabolism
Winner: Kairbaan Hodivala-Dilke & Fevzi Demircioglu
Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3.
Pembrolizumab for Early Triple-Negative Breast Cancer
Winner: Peter Schmid
N Engl J Med (2020) Feb 27;382(9):810-821. doi: 10.1056/NEJMoa1910549.
Winner: Pedro Cutillas
Nat Biotechnol (2020) Jan 20. doi: 10.1038/s41587-019-0391-9. [Epub ahead of print].
Winner: Peter Schmid
J Clin Oncol (2019) Dec 16:JCO1900368. doi: 10.1200/JCO.19.00368. [Epub ahead of print].
Winner: Jack Cuzick
Lancet (2019) Dec 11. pii: S0140-6736(19)32955-1. doi: 10.1016/S0140-6736(19)32955-1. [Epub ahead of print]
Winner: Yaohe Wang
Clin Cancer Res (2019) pii: clincanres.1395.2019. doi: 10.1158/1078-0432.CCR-19-1395.
A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer.
Winner: Li Sun & Ranjit Manchanda
JAMA Oncol (2019) Oct 3. doi: 10.1001/jamaoncol.2019.3323.
Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.
Winner: Paulo Ribeiro
Elife (2019) Sep 30;8. pii: e46592. doi: 10.7554/eLife.46592.
Winner: Peter Schmid
JAMA Oncol. 2019 Aug 29. doi: 10.1001/jamaoncol.2019.2526. [Epub ahead of print]
Winner: Claire Reader and John Marshall
J Pathol. 2019 Jul 1. doi: 10.1002/path.5320. [Epub ahead of print]
Winner: Ana-Rita Pedrosa and Kairbaan Hodivala-Dilke
Cancer Research. June 12, 2019 doi: 10.1158/0008-5472.CAN-18-3934
Winner: Kamil Kranc
Cell Stem Cell. 2019 Jul 3;25(1):137-148.e6. doi: 10.1016/j.stem.2019.03.021. Epub 2019 Apr 25.
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
Winner: Tom Powles
N Engl J Med (2019) Mar 21;380(12):1116-1127. doi: 10.1056/NEJMoa1816714. Epub 2019 Feb 16.
Winner: Peter W. Szlosarek
Clin Cancer Res (2019) Feb 22. pii: clincanres.3729.2018. doi: 10.1158/1078-0432.CCR-18-3729. [Epub ahead of print]
Winner: Victoria Sanz-Moreno
Cell (2019), 176, 1–18 (article online ahead of press)
This paper also won Paper of the Year 2019
Winner: Cindy Neuzillet & Hemant M. Kocher
J Pathol (2018) Dec 21. doi: 10.1002/path.5224. [Epub ahead of print]
Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
Winner: Theresa Arnandis & Susana Godinho
Dev Cell (2018) Nov 19;47(4):409-424.e9. doi: 10.1016/j.devcel.2018.10.026.
Prp8 regulates oncogene-induced hyperplastic growth in Drosophila
Winner: Cecilia H. Fernández-Espartero & Paulo S. Ribeiro
Development (2018) Oct 17. pii: dev.162156. doi: 10.1242/dev.162156. [Epub ahead of print]
Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
Winner: Peter Schmid
N Engl J Med (2018) Oct 20. doi: 10.1056/NEJMoa1809615. [Epub ahead of print]
Winner: Peter Schmid
JAMA Oncol (2018) Sep 13. doi: 10.1001/jamaoncol.2018.4224. [Epub ahead of print]
The evolutionary landscape of colorectal tumorigenesis
Winner: Will Cross & Trevor Graham
Nat Ecol Evol (2018) Aug 31. doi: 10.1038/s41559-018-0642-z. [Epub ahead of print]