A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration

Winner: Stephanie Kermorgant

Sci Signal (2020) 13(637):eaba8627. doi: 10.1126/scisignal.aba8627. 

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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk With Tumor Cells

Winner: Ping-Pui Wong, José M Muñoz-Félix & Kairbaan Hodivala-Dilke

Cell (2020) May 28;S0092-8674(20)30147-1. doi: 10.1016/j.cell.2020.02.003. Online ahead of print.

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A case-control evaluation of 143 single nucleotide polymorphisms for breast cancer risk stratification with classical factors and mammographic density

Winner: Adam Brentnall

Int J Cancer. 2020 Apr 15;146(8):2122-2129. doi: 10.1002/ijc.32541. Epub 2019 Jul 13.

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Cancer associated fibroblast FAK regulates malignant cell metabolism

Winner: Kairbaan Hodivala-Dilke & Fevzi Demircioglu 

Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3.

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Pembrolizumab for Early Triple-Negative Breast Cancer

Winner: Peter Schmid

N Engl J Med (2020) Feb 27;382(9):810-821. doi: 10.1056/NEJMoa1910549.

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Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring.

Winner: Pedro Cutillas

Nat Biotechnol (2020) Jan 20. doi: 10.1038/s41587-019-0391-9. [Epub ahead of print].

Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial.

Winner: Peter Schmid

J Clin Oncol (2019) Dec 16:JCO1900368. doi: 10.1200/JCO.19.00368. [Epub ahead of print].

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Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial.

Winner: Jack Cuzick 

Lancet (2019) Dec 11. pii: S0140-6736(19)32955-1. doi: 10.1016/S0140-6736(19)32955-1. [Epub ahead of print]

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A Virus-Infected, Reprogrammed Somatic cell-derived Tumor cell (VIReST) vaccination regime can prevent initiation and progression of pancreatic cancer.

Winner: Yaohe Wang

Clin Cancer Res (2019) pii: clincanres.1395.2019. doi: 10.1158/1078-0432.CCR-19-1395.

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A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer.

Winner: Li Sun & Ranjit Manchanda

JAMA Oncol (2019) Oct 3. doi: 10.1001/jamaoncol.2019.3323.

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Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.

Winner: Paulo Ribeiro

Elife (2019) Sep 30;8. pii: e46592. doi: 10.7554/eLife.46592.

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Fulvestrant Plus Vistusertib vs Fulvestrant Plus Everolimus vs Fulvestrant Alone for Women With Hormone Receptor-Positive Metastatic Breast Cancer: The MANTA Phase 2 Randomized Clinical Trial.

Winner: Peter Schmid

JAMA Oncol. 2019 Aug 29. doi: 10.1001/jamaoncol.2019.2526. [Epub ahead of print]

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The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

Winner: Claire Reader and John Marshall

J Pathol. 2019 Jul 1. doi: 10.1002/path.5320. [Epub ahead of print]

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Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861

Winner: Ana-Rita Pedrosa and Kairbaan Hodivala-Dilke

Cancer Research. June 12, 2019 doi: 10.1158/0008-5472.CAN-18-3934

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Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukaemia

Winner: Kamil Kranc

Cell Stem Cell. 2019 Jul 3;25(1):137-148.e6. doi: 10.1016/j.stem.2019.03.021. Epub 2019 Apr 25.

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Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

Winner: Tom Powles

N Engl J Med (2019) Mar 21;380(12):1116-1127. doi: 10.1056/NEJMoa1816714. Epub 2019 Feb 16.

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A Phase I study of pegylated arginine deiminase (pegargiminase), cisplatin and pemetrexed in argininosuccinate synthetase 1-deficient recurrent high-grade glioma

Winner: Peter W. Szlosarek

Clin Cancer Res (2019) Feb 22. pii: clincanres.3729.2018. doi: 10.1158/1078-0432.CCR-18-3729. [Epub ahead of print]

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Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

Winner: Victoria Sanz-Moreno

Cell (2019), 176, 1–18 (article online ahead of press)

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

Winner: Cindy Neuzillet & Hemant M. Kocher

J Pathol (2018) Dec 21. doi: 10.1002/path.5224. [Epub ahead of print]

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Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

Winner: Theresa Arnandis & Susana Godinho

Dev Cell (2018) Nov 19;47(4):409-424.e9. doi: 10.1016/j.devcel.2018.10.026.

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Prp8 regulates oncogene-induced hyperplastic growth in Drosophila

Winner: Cecilia H. Fernández-Espartero & Paulo S. Ribeiro

Development (2018) Oct 17. pii: dev.162156. doi: 10.1242/dev.162156. [Epub ahead of print]

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Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

Winner: Peter Schmid

N Engl J Med (2018) Oct 20. doi: 10.1056/NEJMoa1809615. [Epub ahead of print]

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Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast Cancer: A Phase 1 Study

Winner: Peter Schmid

JAMA Oncol (2018) Sep 13. doi: 10.1001/jamaoncol.2018.4224. [Epub ahead of print]

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The evolutionary landscape of colorectal tumorigenesis

Winner: Will Cross & Trevor Graham

Nat Ecol Evol (2018) Aug 31. doi: 10.1038/s41559-018-0642-z. [Epub ahead of print]