My major research interest is investigating the alterations in metabolism that accompany B-cell activation and how this is reflected in the metabolism of low- and high-grade lymphomas including chronic lymphocytic leukaemia/small lymphocytic lymphoma, diffuse large B cell lymphoma and Burkitt lymphoma. Our aim is that an enhanced understanding of the metabolism of normal and malignant B cells will underpin the development of the next generation of anti-metabolic drugs for these diseases. In addition, I am the course director for the MSc Cancer & Clinical Oncology Programme.
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma. The Journal of Clinical Investigation (2022) 2;132(9):e153436. PMID: 35316216
B-cell Receptor Signaling Induced Metabolic Alterations in Chronic Lymphocytic Leukemia Can Be Partially Bypassed by TP53 Abnormalities. HemaSphere (2022) 6(6):e722. PMID: 35747847
Outcomes of patients with hematologic malignancies and COVID-19: A systematic review and meta-analysis of 3377 patients. Blood (2020) 136(25):2881-2892. PMID: 33113551
Trisomy 12 Chronic Lymphocytic Leukemia cells exhibit up-regulation of integrin signaling that is modulated by NOTCH1 mutations. Blood (2014) 123(26):4101-10. PMID: 24829201
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. Blood (2013) 121(9):1612-21. PMID: 23247726
My major research interest is investigating the alterations in metabolism that accompany B-cell activation and how this is reflected in the metabolism of low- and high grade lymphomas including chronic lymphocytic leukaemia/small lymphocytic lymphoma, diffuse large B cell lymphoma and Burkitt lymphoma. We use a variety of proteomic and metabolomic techniques to study these questions in primary patient samples, B-cell lines and murine conditional knockout and transgenic lymphoma models. We are particularly interested in the impact of genetic aberrations of MYC and p53 on the metabolism of lymphoma cells and how this relates to high grade transformation of CLL (Richter syndrome). Our overall aim is that an enhanced understanding of the metabolism of normal and malignant B cells will underpin the development of the next generation of anti-metabolic drugs for these cancers and may also be of benefit in the treatment of non-malignant autoimmune conditions. In addition I am involved in teaching undergraduate and MSc students and am the course director for the MSc Cancer & Clinical Oncology Programme.
I combine my laboratory and translational research programme with clinical practice with the Cancer Centre at Barts Health, with specific emphasis on the treatment of lymphoid malignancies including CLL and lymphoma. In addition to my research in metabolism, I have a particular interest in the role of targeted therapies, immunotherapy and bone marrow transplantation in the treatment of these diseases.
Karen Vousden, The Francis Crick Institute, London, UK
Dinis Calado, The Francis Crick Institute, London, UK
James MacRae, The Francis Crick Institute, London, UK
Louisa James, The Blizzard Institute, QMUL, London, UK
Thomas Kipps, Moores Cancer Center, University of California, San Diego, USA
Laura Rassenti, Moores Cancer Center, University of California, San Diego, USA
2022 update on the clinical outcome of coronavirus disease 2019 in haemato-oncology patients Bradwell S, Hone L, Thorneycroft K et al. Leukemia Research (2022) 119(7)
B-cell Receptor Signaling Induced Metabolic Alterations in Chronic Lymphocytic Leukemia Can Be Partially Bypassed by TP53 Abnormalities Kluckova K, Clear AJ, D'Avola A et al. HemaSphere (2022) 6(7) E722
Guideline for the treatment of chronic lymphocytic leukaemia Walewska R, Parry-Jones N, Eyre TA et al. British Journal of Haematology (2022) 197(7) 544-557
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma D’Avola A, Legrave N, Tajan M et al. Journal of Clinical Investigation (2022) 132(7)
Richter transformation of chronic lymphocytic leukaemia: a British Society for Haematology Good Practice Paper Eyre TA, Riches JC, Patten PEM et al. British Journal of Haematology (2022) 196(7) 864-870
Cessation of ciprofloxacin prophylaxis in haemato-oncology patients. Caldwell L, Bapat A, Drumright L et al. Clin Infect Dis (2021) (1)
The impact of the COVID-19 pandemic on oncology care and clinical trials Ali JK, Riches JC Cancers (2021) 13(7)
Phosphoglycerate Dehydrogenase Is Required for Germinal Center Formation and Is a Therapeutic Target in MYC- driven Lymphoma D'Avola A, Legrave N, Tajan M et al. Blood (2021) 138(1) 717-717
Impact of COVID-19 in patients with lymphoid malignancies. Riches JC World J Virol (2021) 10(2) 97-110
Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics King HW, Orban N, Riches JC et al. Science Immunology (2021) 6(7)For additional publications, please click here
Dr Annalisa D’Avola
Dr Nicola Joseph
Dr Lotte Stiekema
I undertook my undergraduate degree in medical sciences at the University of Cambridge before qualifying from Oxford University Medical School in 2003. I subsequently trained in haematology on the Imperial College training rotation based at Hammersmith hospital.
I developed my research interest during my CRUK Clinical Research Fellowship with Professor Gribben at Barts Cancer Institute where I studied the defects underlying impaired T-cell immunity in chronic lymphocytic leukaemia (CLL) focusing on the impact of lenalidomide, being awarded a PhD in 2013. I stayed in this laboratory for a period of post-doctoral work investigating the expression and function of integrins on CLL cells. I was awarded the Hamblin prize by the UK CLL forum in 2015 for my work documenting the particular differences associated with the presence of trisomy 12.
In 2016, I joined the Centre for Haemato-Oncology in the Barts Cancer Institute as a Clinical Senior Lecturer funded initially as an Intermediate Clinical Fellow by the Wellcome Trust. From 2016-2021 I worked on secondment at the Francis Crick Institute to investigate the metabolism of normal and malignant B cells in collaboration with Professors Karen Vousden and Dinis Calado.
2018: Fellowship of the Higher Education Academy (FHEA)
2015: Fellowship of the Royal College of Pathologists (FRCPath)
2013: PhD, Queen Mary University of London
2006: Membership of the Royal College of Physicians (MRCP)
2003: MB BCh, University of Oxford
2000: MA Medical Sciences, University of Cambridge