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Professor Fran Balkwill
Professor of Cancer Biology

My key area of interest is in cancer and the tumour microenvironment, especially in ovarian cancer. I study the links between cancer and inflammation and research ways of translating this to clinical trials.

Professor Tyson V. Sharp
Professor of Cellular and Molecular Biology

My group’s work focuses on the role of the tumour suppressor protein LIMD1 and its family members Ajuba and WTIP and how their deregulation in normal tissue contributes to the development of lung, renal and breast cancer.

Dr Katiuscia Bianchi
Senior Lecturer

I am interested in all the strategies cancer cells adopt to proliferate and evade cell death, in order to develop new therapeutic strategies. Specifically, my research focuses on how cancer cell metabolism affects tumour growth and investigating how inflammation can drive malignant transformation.

Dr Andrejs Braun
Reader in Genome Regulation

My group is interested in epigenetic regulation of somatic mutagenesis in normal and malignant B cells. We aim to understand how alterations in the nuclear envelope influence B cell chromatin conformation, and what the epigenetic consequences of these alterations are.

Dr Angus James Cameron
Senior Lecturer

My research focuses on kinases regulating cancer cell growth and motility to understand how and when to target them with drugs. My group is currently examining the role of the PKN kinases in malignant progression.

Professor Pedro R. Cutillas
Professor of Cell Signalling and Proteomics

My research group uses unique proteomics and computational approaches to understand how cell signalling pathways driven by the activity of protein kinases contribute to the development of cancer. Increasing this knowledge will be invaluable in advancing personalised cancer therapies.

Dr Mirjana Efremova
Lecturer

We are interested in understanding the cellular and molecular mechanisms that promote cancer cell plasticity and adaptation of tumour cells in metastatic niches and under therapeutic pressure.

Dr Susana Godinho
Reader in Cancer Cell Biology

Our research group focuses on understanding how centrosome amplification impacts tumour progression and how we can target cells with amplified centrosomes to develop new cancer therapies.

Professor Richard Grose
Professor of Cancer Cell Biology

We are interested in how cancer cells interact with each other and the microenvironment. We investigate how cancer cells develop resistance to therapies and design drug combination approaches to overcome this.

Dr Gunnel Halldén
Reader in Cancer Gene Therapy

The research in our team is focused on the development of novel treatment strategies to target prostate and pancreatic cancers using genetically modified viruses that target, replicate and kill cancer cells but leave normal cells unharmed.

Dr Zuzana Horejsi
Lecturer

My lab focuses on discovering functions of phosphorylation induced by damaged DNA in normal and cancer cells, and investigating the role of different phosphorylation events in cancer development.

Dr Li Jia
Senior Lecturer

I am interested in studying the effects of the inflammatory microenvironment on disease progression and resistance to treatment in haematological malignancies with emphasis on survival and mechanisms of treatment resistance in chronic lymphocytic leukaemia and B cell lymphoma.

Dr Stéphanie Kermorgant
Reader in Cellular Oncology

We study the role of growth factor receptor signalling and intracellular trafficking (movement inside cells) in tumour growth and metastasis in the view of improving cancer therapy.

Dr Sergey Krysov
Senior Lecturer

My studies concentrate on the immunogenetics of human B cell malignancies, such as chronic lymphocytic leukaemia, follicular lymphoma and the role for B cell receptor in the development of B cell lymphoma and leukaemia.

Dr Sarah Martin
Reader in Cancer Cell Biology; Director of Graduate Studies for Research (BCI)

Our research is based on exploiting DNA repair defects in cancer for the identification of new personalised therapies. We use compound and siRNA screening to identify new therapeutics for tumours based on their specific DNA repair status.

Dr Paulo Ribeiro
Senior Lecturer

Our research group is interested in uncovering the molecular mechanisms regulating tissue growth, invasion and metastasis using the fruit fly Drosophila melanogaster as a genetically tractable model organism.

Dr John Riches
Clinical Senior Lecturer

My major research interest is understanding the metabolism of chronic lymphocytic leukaemia and lymphoma with the aim that this will underpin the development of the next generation of anti-metabolic drugs for these diseases.

Dr Kevin Rouault-Pierre
Lecturer

My main research interests are in haematopoietic stem cells (HSCs) and leukemic initiating cells. I seek to understand how intrinsic and extrinsic signals are integrated by normal and malignant stem cells.

Dr Tanya Soliman
Lecturer

My research focuses on kinase biology and how kinase signalling pathways are hijacked in cancer. We combine computational biology with proteomics and cell biology to uncover novel ways to target these dysregulated networks.

Dr Pedro Casado-Izquierdo

My work is based on studying signalling networks in AML primary samples in order to predict responses to kinase inhibitors.

Dr Marta Crespi-Sallan

My research is focused on describing the mechanisms underlying Lamin B1 nuclear disassembly in B-cell normal development and how a dis-regulated Lamin B1 removal pathway could lead to several haematological malignancies within the germinal centre in secondary lymph organs.

Dr Danilo Cucchi

My main research is focused on the identification of DNA damage signatures that predict response to immune checkpoint blockade. I am also interested in the role of metabolism in the biology of both cancer cells and immune cells.

Dr Jesus Gomez Escudero

I am involved in some projects that are focused in the stroma components of a tumour, particularly the endothelial vessels, and its potential role in some key processes including chemotherapy or metastasis.

Dr Michelle Goulart

My research is focused in understanding the tumour-stroma interactions in pancreatic cancer and the identification of potential biomarkers.

Dr Damien Goutte-Gattat

I am using fruit flies to investigate the role of tumour heterogeneity in the development of glioblastoma and the acquisition of resistance to chemotherapy.

Dr Maruan Hijazi-Vega

My work is focused on producing systematic classification of phosphorylation sites detectable by mass spectrometry that will provide new insights into the complexity and topology of kinase signalling.

Dr Kubra Karaosmanoglu Yoneten

Our research is focused on metabolic stresses accompanying activation of oncogenes. We are investigating cell responses to metabolic stresses in order to deeply understand these mechanisms and propose metabolic targets for cancer therapies.

Dr Oscar Maiques

My research will focus on studying Myosin II function during melanoma progression and its cross-talk with inflammatory and immune responses.

Dr Tizong Miao

My project aims to identify strategies to boost host anti-cancer immune response through enhanced oncolytic efficiency of oncolytic viruses by small molecules.

Dr Marie Nollet

Our group has shown that internalised c-Met traffics through endomembranes positive for LC3B and Beclin1. Furthermore, c-Met sustains signalling from Autophagy Related Endomembranes, ARE. We hypothesised therefore that the AREs supporting c-Met trafficking and signalling belong to a novel non-canonical pathway.

Dr Meryem Ozgencil

My project focuses on identifying phosphorylation regulated interactions of DNA Damage repair proteins, and investigating the functional role of these interactions for DNA damage repair and cancer development.

Dr Kunal Shah

I am studying how the tumour suppressor gene LIMD1 functions in the microRNA pathway, a gene regulatory pathway that is often dysregulated in cancer.