Dr Kevin Rouault-Pierre

BSc, MSc, PhD
Lecturer
Group Leader
Research Focus

My main research interests are in haematopoietic stem cells and leukemic initiating cells. I seek to understand how intrinsic and extrinsic signals are integrated by normal and malignant stem cells.

Key Publications

Preclinical modeling of myelodysplastic syndromes. Leukemia (2017) 31(12):2702-2708. PMID: 28663577

Myelodysplastic synrome can propagate from the multipotent progenitor compartment. Haematologica (2016) 102(1):e7-e10. PMID: PMC5210239

SF3B1 mutant MDS initiating-cells may arise from the haematopoietic stem cell compartment. Nature Communications (2015) 6:10004. PMID: 26643973

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress. Cell Stem Cell (2013) 13(5):549-63. PMID: 24095676

Major Funding
  • 2019-2021- Academy of Medical Sciences Springboard Award, Stress integration in normal and malignant haematopoietic stem cells, £99,986
  • 2017-2021- Kay Kendall Leukaemia Fund, Stress Integration in Heamatopietic Cells, £287,162.14
Other Activities
  • Member of the European Haematology Association
  • Member of the Société Française d'Hématologie
Research

Myelodysplastic Syndromes (MDS) and Acute myeloid leukaemia (AML) are both clonal diseases that harbour MDS stem cells (MDS-SC) and pre-leukemic cells, respectively. Various studies have demonstrated that acquired mutations in haematopoietic cells' genes can lead to clonal fitness and eventually to propagation of the disease. Understanding the switch between clonal haematopoiesis and clonal disease is one of the major challenges of the scientific community, which highlights the need to unravel how epigenetic/spliceosome stresses are integrated by stem cells and dictate their clonal fate.

Other Activities
  • Member of the European Haematology Association
  • Member of the Société Française d'Hématologie
Major Funding
  • 2019-2021- Academy of Medical Sciences Springboard Award, Stress integration in normal and malignant haematopoietic stem cells, £99,986
  • 2017-2021- Kay Kendall Leukaemia Fund, Stress Integration in Heamatopietic Cells, £287,162.14
Team

Posdoctoral Researchers
Dr Celine Philippe

PhD students
Doriana Di Bella, Weiwei Tang

Biography

I have been developing my expertise on haematopoietic stem cells and multiple cancer fields throughout my career and have beneficiated in particular of the Francis Crick Institute’s world-class environment, with one of the world leaders in the haematology and stem cell field, Dr Dominique Bonnet. The work conducted in Dr Bonnet’s group in collaboration with Prof Mufti from King’s College Hospital has significantly contributed to providing me with the tools and knowledge for the project I am developing.

In September 2017 I was awarded the Kay Kendall Leukaemia intermediate fellowship and joined the Barts Cancer Institute at the Centre for Haemato-Oncology led by Prof John Gribben.

Upcoming Events
  1. Thursday Seminar Series – Dr Benjamin Werner

    November 21 @ 12:30 pm - 1:30 pm
  2. Miltenyi Biotec Exhibition – Friday 22nd November 2019

    November 22 @ 9:00 am - 1:00 pm
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