Dr Jeff Davies
Reader in Haemato-oncology and Honorary Consultant
My group works on developing novel approaches to improve efficacy and safety of allogeneic stem cell transplantation and adoptive immunotherapy as treatments for blood cancers. We focus on T-cell alloreactivity in the context of stem cell transplantation and immunotherapy.
Dr Paolo Gallipoli
Clinical Senior Lecturer in Haemato-Oncology
My research interests focus on mechanisms of disease initiation and maintenance and the identification and validation of novel therapeutic targets in myeloid leukaemias.
Dr Miguel Ganuza
Lecturer
Our goal is to identify mechanisms that support haematopoietic stem cell function and understand how the leukaemic stem cells “play” with these mechanisms to thrive.
Professor John Gribben
Professor of Medical Oncology
My primary research interests include the immunotherapy of cancer (including stem cell transplantation), the identification of B-cell-tumour antigens; and the detection and treatment of minimal residual disease in leukaemia and lymphoma.
Professor Kamil R. Kranc
Clinical Professor of Haematology
Our research aims to understand the biology of leukaemia stem cells and identify tricks they use to escape treatments. My group employs multidisciplinary approaches to understand how HSCs chose to self-renew or differentiate and how these cell fate decisions are affected under pathological conditions to generate leukaemic stem cells.
Dr Stuart McDonald
Reader in Gastrointestinal Biology
Our main research areas are focused on understanding the evolution of Barrett’s oesophagus to cancer, field cancerisation of the human stomach, and clonal expansion in ductal carcinoma in situ of the human breast.
Dr Jessica Okosun
Clinical Senior Lecturer
My research focuses on understanding the genetic and molecular mechanisms that underlie the initiation and progression of B-cell non-Hodgkin’s lymphomas in order to define clinically-relevant biomarkers.
Dr Kevin Rouault-Pierre
Lecturer
My main research interests are in haematopoietic stem cells (HSCs) and leukemic initiating cells. I seek to understand how intrinsic and extrinsic signals are integrated by normal and malignant stem cells.
Dr Bela Wrench
Clinical Senior Lecturer
My research focuses on the fundamental aspects of leukaemia initiating cell (LIC) biology in adult acute lymphoblastic leukaemia, with the aim of gaining fundamental insight into the underlying biology of LICs to reveal dependencies that are tractable targets for therapy.
Dr Hannah Armes
The aim of my research project is to identify and functionally characterise candidate disease genes in familial leukaemia.
Dr Natacha Bohin
My research focuses on employing multidisciplinary approaches to characterise RNA modifiers and explore their therapeutic potential to eradicate leukaemic stem cells, and to achieve haematopoietic stem cell expansion for therapy.
Dr Sam Burgess
My research is primarily focused on exploring how the bone marrow niche regulates haematopoietic stem cell development and leukaemia progression.
Dr Christopher Mapperley
My research is focused on investigating how the epitranscriptome regulates normal and malignant haematopoiesis.
Dr Maximilian Mossner
My research is focussed on the disturbed epigenomic landscape within pancreatic tumours.
In particular, I investigate the bi-directional epigenetic reprogramming between the tumour microenvironment and pancreatic cancer stem cells that leads to cooperative tumour outgrowth.
Dr Kunal Shah
I am studying how the tumour suppressor gene LIMD1 functions in the microRNA pathway, a gene regulatory pathway that is often dysregulated in cancer.