Centre for Haemato-Oncology

Welcome to the Centre for Haemato-Oncology, where our main mission is to find cures for haematologic malignancies. We are a centre of excellence in state-of-the-art research and clinical translation, which brings together internationally-recognised basic scientists with top clinical  academics. Our central aim is to understand the biology of leukaemias and lymphomas and harness this knowledge to identify new treatment strategies. Working closely together with the Haemato-oncology department at the St Bartholomew’s Hospital Cancer Centre we are uniquely well placed to implement our findings in clinical practice. Moreover, our Centre is embedded in Barts and The London School of Medicine and Dentistry, one of the UK’s top medical schools, thus offering excellent opportunities for multidisciplinary collaborations.

Our main research themes and their associated faculty include:

  1. Stem cell biology and normal haematopoiesis (Laboratories: Ficz, Ganuza, Kranc, Rouault-Pierre)
  2. Biology and therapeutic targeting of leukaemia (Laboratories: Gribben, Gallipoli, Kranc, Krysov, Riches, Rouault-Pierre, Wrench, Cutillas)
  3. Pathogenesis and treatment of lymphomas (Laboratories: Braun, Okosun, Riches, Fitzgibbon)
  4. Improving immunotherapy in blood malignancies (Laboratories: Davies, Gribben, Le Dieu)

Contact us

Centre Lead: Professor John Gribben

Deputy Centre Lead: Professor Kamil Kranc

Lab Manager: Dr Rebecca Gresham

Centre Administrator: Elen McCabe

3rd Floor, John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Recent Publications

    • The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. J Exp Med (2021) 218(3):e20200829. PMID: 33156926
    • Retinoic acid-responsive CD8 effector T-cells are selectively increased in IL-23-rich tissue in gastrointestinal GvHD. Blood (2020) blood.2020005170. PMID: 32905596
    • Clinical outcome of coronavirus disease 2019 in haemato-oncology patients. Br J Haematol (2020) bjh.16852. PMID: 32420609
    • Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation. Nat Commun (2020) 11(1):3671. PMID: 32699299
    • Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells. Cell Stem Cell (2020) 26(3):299-301. PMID: 32142657
    • IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution. Blood (2020) 135(11):834-844. PMID: 31932843
    • Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metab (2020) 32(5):829-843.e9. PMID: 32966766
    • A randomised Phase II trial of Hydroxychloroquine and Imatinib versus Imatinib alone for patients with Chronic Myeloid Leukaemia in Major Cytogenetic Response with residual disease. Leukemia (2020) 34(7):1775-1786. PMID: 31925317
See more
  • Outcomes of patients with hematologic malignancies and COVID-19: A systematic review and meta-analysis of 3377 patients. Blood (2020) blood.2020008824. PMID: 33113551
  • Clones assemble! The clonal complexity of blood during ontogeny and disease. Experimental Hematology (2020) 83:35-47. PMID: 32006606
  • The global clonal complexity of the murine blood system declines throughout life and after serial transplantation. Blood (2019) 133(18):1927-1942. PMID: 30782612
  • Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia. Cell Stem Cell (2019) 25(1):137-148.e6. PMID: 31031138
  • Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR. Nat Metab (2019) 1(8):775-789. PMID: 31579886
  • AUGMENT: A Phase III Study of Lenalidomide Plus Rituximab Versus Placebo Plus Rituximab in Relapsed or Refractory Indolent Lymphoma. J Clin Oncol (2019) 37(14):1188-1199. PMID: 30897038

Latest News

  • Miguel Ganuza is the recipient of a Career Development Award from the Medical Research Council. The project will look at 'Genetic identification and functional dissection of the bone marrow niches that support haematopoietic stem cells and leukaemic stem cells.' Read our news story to find out more.
  • Miguel Ganuza has been awarded a John Goldman Fellowship from Leukaemia UK to look at 'Deconvoluting novel pathways leading to clonal haematopoiesis.'
  • Researchers from the Centre attended the American Society of Hematology (ASH) Annual Meeting and Exposition, which this year took place in Orlando, Florida on 7th-10th December. Oral presentations were given by Dr Jessica Okosun, Dr Joseph Taylor, Dr James Aries and Dr Robin Sanderson. Poster presentations were given by Dr Findlay Copley, Dr Emily Saunderson and Arantxa Romero-Toledo. Find out more here.
  • Bloodwise supporters recently visited the Centre as part of the Bloodwise Laboratory Tour programme. Find out more about the day here.
  • Dr Hannah Lawson from the Kranc Group won the Translational Medicine award during the William Harvey Day 2019.
  • Congratulations to Prof John Gribben who has been announced as the new President for the European Hematology Association.

Areas of focus

Acute myeloid leukaemia
DLBCL - CD20 IHC
Lymphoma
FL cropped
Acute lymphoblastic leukaemia
DLBCL immunofluorescence - PMCH FITC
Chronic lymphocytic leukaemia
Follicular lymphoma - H&E
Stem Cell Biology
Hodgkins - EBV in situ hydribisation - blue
Immunotherapy
Vessels (CD31) CLL/SLL

Funders

Research in the Centre for Haemato-Oncology is kindly funded by Cancer Research UK, Blood Cancer UK, Barts Charity, The Kay Kendall Leukaemia Fund and Medical Research Council.