Professor Thomas Powles

MBBS, MRCP, MD
Professor of Genitourinary Oncology,
Director, Barts Cancer Centre,
Lead for Solid Tumour Research
Group Leader
Research Focus

My main research interests are in genital and urinary cancers, and I lead a spectrum of clinical studies from phase I to randomised phase III. The majority of the studies are translational phase II studies investigating novel targeted and immune therapies.

Key Publications

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma. N Engl J Med (2019) 380(12):1116-1127. PMID: 30779529

Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial. Lancet (2019) 393(10189):2404-2415. PMID: 31079938

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature (2018) 554(7693):544-548. PMID: 29443960

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma. Nat Med (2018) 24(6):749-757. PMID: 29867230

Major Funding
  • 2015-2020- Astrazeneca UK Limited, PDL-1 combination targeted therapy with AZ6094 in metastatic renal cancer (CALYPSO), £3,199,998
  • 2015-2020- F Hoffmann-La Roche Ltd, Treatment of transitional cell carcinoma of the bladder-ABACUS, £2,644,429

Other Activities
  • NCRN bladder cancer CSG
  • NCRN renal cancer CSG
  • NCRN translational oncology group
  • NCRN CRPC studies group
Research

I am the lead for solid tumor research at Barts Cancer Institute. I also lead the genitourinary (GU) cancer group at BCI.

My work focuses on a spectrum of clinical studies from phase I to randomised phase III. The majority of the studies are translational phase II studies investigating novel targeted and immune therapies. They exploit functional imaging and tissue collection.

Alongside these trials, our research focuses on correlation of novel biomarkers and aims to define markers that are of prognostic value and can predict response or resistance to therapy.

I have written over 100 peer review papers in this area and have grant income from national and international funding bodies.

I am on the editorial board of a number of journals and am part of the faculty for the major global oncology meetings.

Other Activities
  • NCRN bladder cancer CSG
  • NCRN renal cancer CSG
  • NCRN translational oncology group
  • NCRN CRPC studies group
  • EORTC-GU executive committee
  • ESMO faculty for GU cancer
  • Editorial board of Clinical Genitourinary Cancer
  • Co chair of trans Atlantic bladder cancer consortium
  • International guidelines for testis cancer and renal cancer
Major Funding
  • 2015-2020- Astrazeneca UK Limited, PDL-1 combination targeted therapy with AZ6094 in metastatic renal cancer (CALYPSO), £3,199,998
  • 2015-2020- F Hoffmann-La Roche Ltd, Treatment of transitional cell carcinoma of the bladder-ABACUS, £2,644,429
  • 2013-2018- Millenium Pharmaceuticals Inc, NEPTUNE study of neoadjuvant TAK-700 and leuprorelin acetate versus surgery alone in intermediate and high risk clinically localized, £979,682
  • 2012-2017- AstraZeneca UK Limited, Comparing AZD2014 and EVEROLIMUS, £906,000
  • 2010-2015- GlaxoSmithKline Research & Development, A phase II study investigating upfront pazopanib in metastatic clear cell renal cancer (PANTHER), £1,155,763
Recent Publications

Clinical outcome after progressing to frontline and second-line Anti–PD-1/PD-L1 in advanced urothelial cancer[Formula presented] Gómez de Liaño Lista A, van Dijk N, de Velasco Oria de Rueda G et al. European Urology (2020) 77(7) 269-276

EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer—An International Collaborative Multistakeholder Effort[Formula presented]: Under the Auspices of the EAU-ESMO Guidelines Committees Witjes JA, Babjuk M, Bellmunt J et al. European Urology (2020) 77(7) 223-250

Management of Sporadic Renal Angiomyolipomas: A Systematic Review of Available Evidence to Guide Recommendations from the European Association of Urology Renal Cell Carcinoma Guidelines Panel Fernández-Pello S, Hora M, Kuusk T et al. European urology oncology (2020) 3(7) 57-72

Outcomes based on age in the phase III METEOR trial of cabozantinib versus everolimus in patients with advanced renal cell carcinoma Donskov F, Motzer RJ, Voog E et al. European Journal of Cancer (2020) 126(7) 1-10

Cytoreductive nephrectomy: Does CARMENA (Cancer du Rein Metastatique Nephrectomie et Antiangiogéniques) change everything? Grant M, Szabados B, Kuusk T et al. Current Opinion in Urology (2020) 30(7) 36-40

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial Petrylak DP, de Wit R, Chi KN et al. The Lancet Oncology (2020) 21(7) 105-120

Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol. In press Kamoun A, de Reyniès A, Allory Y et al. European Urology (2020) (7)

The evolving role of PD-L1 testing in patients with metastatic urothelial carcinoma Powles T, Walker J, Andrew Williams J et al. Cancer Treatment Reviews (2020) 82(7)

Treatment Choices for Front-line Metastatic Clear Cell Renal Cancer Powles T European Urology (2020) (7)

PRISM protocol: a randomised phase II trial of nivolumab in combination with alternatively scheduled ipilimumab in first-line treatment of patients with advanced or metastatic renal cell carcinoma Buckley HL, Collinson FJ, Ainsworth G et al. BMC Cancer (2019) 19(7)

For additional publications, please click here
Biography

I qualified from St Bartholomew’s Medical School in 1996 and trained in medical oncology at Imperial College. I completed post-graduate training in oncology in 2005 and received an MD from the University of London in 2006. My thesis was in mechanisms of resistance to therapy in urology cancers.

Upcoming Events
  1. Thursday Seminar Series – Dr Martin Cohn

    February 27 @ 12:30 pm - 1:30 pm
  2. The London Pancreas Workshop 2020

    May 1 @ 9:30 am - 4:30 pm
  3. 2020 Circulating Cancer Biomarker Symposium

    May 4 @ 9:00 am - 5:30 pm
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