For over 25 years I have studied the biology of tumour invasion with a particular interest in the roles of the adhesion molecules expressed on the cell surface that mediate this process. Our group concentrates on the study of integrins that are the principal family of adhesion molecules that mediate interaction between cells and the extracellular matrix (ECM).
My main research interests are in genital and urinary cancers, leading a spectrum of clinical studies from phase I to randomised phase III. The majority of the studies are translational phase II studies investigating novel targeted and immune therapies.
My research focuses on cutaneous melanoma biology, a highly aggressive and metastatic cancer. I aim to get more insights into signalling pathways underlying melanoma progression and responses to current therapies. In particular, I am interested in the role of the actomyosin cytoskeleton in drug resistance.