My group studies how different populations of immune cells in the tumour microenvironment cross-talk in order to establish a “favourable” niche in metastasis.
Metastatic-niche labelling reveals parenchymal cells with stem features. Nature (2019) 572(7771):603-608. PMID: 31462798
Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization. Cell Reports (2015) 13(11):2456-69. PMID: 26670048
The EMT universe: space between cancer cell dissemination and metastasis initiation. Critical reviews in oncogenesis (2014) 19(5):349-61. PMID: 25404150
T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications. PNAS (2011) 108(29):11912-7. PMID: 21730189
The interplay between the cancer cells and the cells in the tumour microenvironment (TME) is critical for the metastatic growth. Our knowledge of how the metastatic “niches” support tumour growth is still very limited, particularly at the early stage of the disease, due to the technical challenge to discriminate TME cells within the whole metastatic tissue.
Cherry-niche, a novel labelling system I developed, allows cancer cells to directly identify their surrounding cells in the metastatic microenvironment (Ombrato et al., Nature 2019). Labelled tissue cells, which represent the local metastatic niche, can be spatially discriminated, isolated from and compared to the entire tissue. Now we have the opportunity to understand how these cells change in the local niche environment.
My lab studies how different immune cell populations interact in metastasis to identify the key events required to establish a favourable “niche” to support tumour growth, in order to propose new therapeutic approaches.
To address these issues, my research aims to answer the following questions:
1. How does the immune-niche evolve in metastasis?
My lab studies how the composition of the “immune-niche” changes, both quantitatively and qualitatively during metastatic disease progression.
2. What makes a niche pro-metastatic?
Several changes occur at the distant tissue when tumour cells colonise it. However, only some of these changes will be critically required for metastatic progression.
We aim to identify the key changes in the metastatic microenvironment that support tumour growth and find potential therapeutic strategies to prevent them.