We aim to identify genetic alterations that influence cancer development, progression and therapeutic responses, in particular for prostate cancer, and further develop them into biomarkers for cancer diagnosis and therapeutic stratification, with a current focus on circulating biomarkers.
Circulating tumour cells for early detection of clinically relevant cancer. Nat Rev Clin Oncol (2023). PMID: 37268719
Non-invasive Detection of Clinically Significant Prostate Cancer Using Circulating Tumor Cells. J Urol (2020) 203(1):73-82. PMID: 31389764
The novel association of circulating tumor cells and circulating megakaryocytes with prostate cancer prognosis. Clin Cancer Res (2017) 23(17):5112-5122. PMID: 28615267
DNA replication-dependent induction of gene proximity by androgen. Hum Mol Genet (2015) 15;24(4):963-71. PMID: 25281662
Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014) 232(5):566-77. PMID: 24407904
I have set up a research team devoted to cancer genetic studies and biomarker development, in particular in male urological cancers. The mission of the research team is to reduce mortality and morbidity of cancer patients by understanding cancer development and progression mechanisms and facilitating precision medicine through the development of efficient cancer detection, prognostic and treatment response prediction/monitoring biomarkers.
Our past work has been mainly focused on identification of genetic alterations and genetic mechanisms in cancer development, progression and therapeutic response. Recently, our research work moved into circulation biomarker development, including CTCs, exosome and other cells, for cancer diagnosis, prognosis and prediction/monitoring of cancer progression and therapeutic response.
There are currently two main research areas of interest:
Protocol for a prospective study evaluating circulating tumour cells status to predict radical prostatectomy treatment failure in localised prostate cancer patients (C-ProMeta-1) Al-Hammouri T, Almeida-Magana R, Lawrence R et al. BMC Cancer (2023) 23(7)
Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry Darst BF, Shen J, Madduri RK et al. American Journal of Human Genetics (2023) 110(7) 1200-1206
Circulating tumour cells for early detection of clinically relevant cancer Lawrence R, Watters M, Davies CR et al. Nature Reviews Clinical Oncology (2023) 20(7) 487-500
The potential of using circulating tumour cells and their gene expression to predict docetaxel response in metastatic prostate cancer Davies CR, Guo T, Burke E et al. Frontiers in Oncology (2023) 12(7)
Discovery and validation of bladder cancer related excreted nucleosides biomarkers by dilution approach in cell culture supernatant and urine using UHPLC-MS/MS Chang Q, Chen P, Yin J et al. Journal of Proteomics (2023) 270(7)
Hsa_circ_0094606 promotes malignant progression of prostate cancer by inducing M2 polarization of macrophages through PRMT1-mediated arginine methylation of ILF3 Zhang Y, Wang K, Yang D et al. Carcinogenesis (2023) 44(7) 15-28
Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study Burns D, Anokian E, Saunders EJ et al. European Urology (2022) 82(7) 201-211
Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score Huynh-Le MP, Karunamuni R, Fan CC et al. Prostate cancer and prostatic diseases (2022) 25(7) 755-761
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study. Morales Berstein F, McCartney DL, Lu AT et al. Elife (2022) 11(2)
https://www.ncbi.nlm.nih.gov/pubmed/35346416
Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging. Zhang Y, Hollis D, Ross R et al. Materials (Basel) (2022) 15(1)
https://www.ncbi.nlm.nih.gov/pubmed/35269067
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