Centre for Cancer Cell and Molecular Biology

Welcome to the Centre for Cancer Cell and Molecular Biology, where our main mission is to elucidate the fundamental mechanisms of cancer cell biology and how these can be therapeutically targeted. We are a centre of excellence in state-of-the-art research and clinical translation, which brings together internationally-recognised basic science and clinical academics. Our central aim is to understand the basic biology of cancer cells and harness this knowledge to identify new treatment strategies. Our Centre is embedded in one of the UK’s top medical schools thus offering excellent opportunities for multidisciplinary collaborations.

Contact us

Centre Lead: Professor Tyson Sharp

Deputy Centre Lead: Dr Sarah Martin / Dr Michelle Lockley

Ground Floor, John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Recent Publications

  • Subcellular mRNA localization regulates ribosome biogenesis in migrating cells. Dev Cell (2020) 55(3):298-313.e10. PMID: 33171110
  • A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun (2020) 11(1):1851. PMID: 32296040
  • MLH1 deficiency leads to deregulated mitochondrial metabolism. Cell Death & Disease, In Press
  • Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Dev Cell (2018) 47(4):409-424. PMID: 30458137
  • A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Mol Med (2018) PMID: 29930174

Latest News

  • Congratulations to Dr Lovorka Stojic who has received a Cancer Research UK Career Establishment Award to investigate the the role of long noncoding RNAs in genome stability and cancer. Find out more.
  • Dr Lovorka Stojic and Dr Faraz Mardakheh presented their research at the RNA UK 2020 meeting, which took place on 24-26 January in Windermere, UK.
  • Michelle Lockley gave a keynote lecture at the International Germ Cell Tumour Conference in Cambridge (15th-18th September).
  • Susana Godinho has been awarded an MRC grant for over £600,000 for 'Dissecting the role of extra centrosomes-induced exosome secretion in PDAC microenvironment.'

Areas of focus

RNA biology
RNA biology
Genome stability
Clinical translation
Drug resistance
Scientist hand over petri dishes for an experiment in a science research lab
Chromosomal biology
Tracking the position and behaviour of individual chromosomes during mitosis. Here chromosome 1 is marked by white fluorescence in-situ hybridisation probes.
Cytoskeletal regulation