Centre for Cancer Genomics and Computational Biology

In the Centre for Genomics and Computational Biology, we employ unbiased high-throughput sequencing, mass spectrometry and multispectral imaging of tumour samples to gain unique insights into cancer evolution, genetics and cell signalling through from premalignancy to metastatic disease. We are internationally recognised for our work on lymphoma, leukaemia and gastrointestinal cancers, and the creation of computational tools to extract maximum value from Big Data. Our ambition is to see translation of new knowledge into improvements in early cancer detection and precision medicine.

Contact us

Centre Lead: Professor Jude Fitzgibbon

Deputy Centre Lead: Professor Trevor Graham

John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Recent Publications

  • Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR. Nat Metab (2019) 1(8):775-789. PMID: 31579886
  • Measuring Clonal Evolution in Cancer with Genomics. Annu Rev Genomics Hum Genet (2019) 20:309-329. PMID: 31059289
  • Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. Cell Rep (2019) 27(8):2524. PMID: 31116993
  • Evolutionary history of human colitis-associated colorectal cancer. Gut (2019) 68(6):985-995. PMID: 29991641
  • The feedback between selection and demography shapes genomic diversity during coevolution. Science Advances (2019) 5(10) DOI: 10.1126/sciadv.aax0530

Latest News

  • Pedro Cutillas was awarded funding from Innovate UK and private investors totalling £950k to found Kinomica Ltd., a QMUL spin-out company that aims to translate research from the Cutillas group into companion diagnostics.
  • Kit Curtius was awarded CRUK Early Detection Primer Award to study the molecular ageing of premalignancy Barrett’s oesophagus in a population-representative sample of patients spanning paediatric to older age groups, co-PI Prof Helen Coleman Queen’s University of Belfast.
  • Jun Wang, co-investigator led by Prof Irene Leigh Institute of Dentistry QMUL, was awarded the Sanofi and Regeneron Investigator Sponsored Studies (ISS) Program, £639K, to investigate “Personalised medicine for immunotherapy of cutaneous squamous cell carcinoma (PERMEDID)”.
  • Kit Curtius presented at the Digestive Disease Week Distinguished Abstract Plenary “Quantifying evolution of early dysplastic lesions in ulcerative colitis predicts future colorectal cancer risk” in San Diego, CA, USA (May 2019).
  • Stuart McDonald presented at McGill University - ‘’Inflammation in Cancer’’ Montreal (July 2019).
  • Benjamin Werner presented at the 7th International Summer School in Ecology and Evolution - ”A brief history of somatic evolution”,  SYSU, Guangzhou, China, (August 2019)
  • Trevor Graham presented at CNIO - “Heterogeneity and Evolution in Cancer” Madrid (Sept 2019)
  • Jude Fitzgibbon presented at the European Society for Medical Oncology, on the Biology and Early diagnosis of blood malignancies, in Barcelona (Sep 2019)
  • Jude Fitzgibbon presented at the European School of Haematology - ‘’New Concepts in Lymphoid Malignancies’’ in Estoril (Oct 2019)

Areas of focus

Gastrointestinal cancers
Barrett's oesophagus 1 - McDonald lab
Barrett's oesophagus 2 - McDonald lab
Haematological malignancies
FISH DLBCL - Andrew Clear 2
Stem cells in the evolution of metaplasia
Cancer genomics and evolution
Mathematical and computational biology
Functional non-coding mutations in cancer
Cell signalling and drug resistance