Centre for Cancer Genomics and Computational Biology

In the Centre for Genomics and Computational Biology, we employ unbiased high-throughput sequencing, mass spectrometry and multispectral imaging of tumour samples to gain unique insights into cancer evolution, genetics and cell signalling through from premalignancy to metastatic disease. We are internationally recognised for our work on lymphoma, leukaemia and gastrointestinal cancers, and the creation of computational tools to extract maximum value from Big Data. Our ambition is to see translation of new knowledge into improvements in early cancer detection and precision medicine.

Contact us

Centre Lead: Professor Jude Fitzgibbon

Deputy Centre Lead: Professor Trevor Graham

John Vane Science Centre,
Charterhouse Square,
London EC1M 6BQ

Recent Publications

  • The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition. Nature Communications (2020) 11(1):1396–14. PMID: 32170202
  • CellPhoneDB: Inferring cell-cell communication from combined expression of multi-subunit receptor-ligand complexes. Nature Protocols (2020) 15(4):1484-1506. PMID: 32103204
  • Strands of evidence about cancer evolution. Nature (2020) 583(7815):207-209. PMID: 32620881
  • Measuring single cell divisions in human tissues from multi-region sequencing data. Nat Commun (2020) 11(1):1035. PMID: 32098957
  • The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants. Nat Commun (2020) 11(1):1044. PMID: 32098966
  • Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring. Nat Biotechnol (2020) 38(4):493-502. PMID: 31959955

Latest News

  • PhD candidate Vinaya Srirangam Nadhamuni won the People's Choice award in the 2020 Vitae Three Minute Thesis competition national finals. Huge congratulations! Watch Vinaya's finals presentation.
  • Dr. Tanya Soliman and Dr. Mirjana Efremova have joined the Centre to establish their own research groups. Dr. Soliman’s work focuses on kinase biology and how kinase signalling pathways hijack cancer. Dr. Efremova's work looks at the cellular and molecular mechanisms that promote cancer cell plasticity and adaptation in the metastatic niche.
  • Sarah McClelland was awarded £320k from an Astra Zeneca research collaboration to investigate genomic signatures of replication stress.
  • Benjamin Werner was awarded a $1 million collaborative grant from the Human Frontiers in Science Program to work on problems of somatic evolution integrating knowledge from cancer, seagrass and corals.

Areas of focus

Gastrointestinal cancers
Barrett's oesophagus 1 - McDonald lab
Haematological malignancies
FISH DLBCL - Andrew Clear 2
Barrett's oesophagus 2 - McDonald lab
Stem cells in the evolution of metaplasia
Cancer genomics and evolution
Cell signalling and drug resistance
Mathematical and computational biology
Functional non-coding mutations in cancer
Cancer cell plasticity
Cancer Cell Plasticity_Mirjana Efremova