In the Centre for Genomics and Computational Biology, we employ unbiased high-throughput sequencing, mass spectrometry and multispectral imaging of tumour samples to gain unique insights into cancer evolution, genetics and cell signalling through from premalignancy to metastatic disease. We are internationally recognised for our work on lymphoma, leukaemia and gastrointestinal cancers, and the creation of computational tools to extract maximum value from Big Data. Our ambition is to see translation of new knowledge into improvements in early cancer detection and precision medicine.
Deputy Centre Lead: Dr Sarah McClelland
John Vane Science Centre,
London EC1M 6BQ
Since 2016, the BCI’s Haemato-Oncology tissue bank has released 924 vials of primary tissue to researchers from five institutions as part of a CRUK funded Programme on Poor Risk Acute Myeloid Leukaemia. The tissue collection, archiving and allied clinical information was generously supported by an award from the Medical College of St Bartholomew’s Hospital Trust. (Photo, left to right: Adrian Kontor, Tissue Bank Technician, and Ana Rio-Machin, lead lab researcher on the project).
Gabbutt, C., Schenck, R.O., Weisenberger, D.J. et al. Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues. Nat Biotechnol (2022). https://doi.org/10.1038/s41587-021-01109-w. CC BY 4.0
Rio-Machin, A., Vulliamy, T., Hug, N. et al. The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants. Nat Commun (2020) 11, 1044. https://doi.org/10.1038/s41467-020-14829-5. CC BY 4.0
Jackson, SS., Nambiar, KZ., O'Calloghan, S., Berner, AM. Understanding the role of sex hormones in cancer for the transgender community. Trends in Cancer (2022) DOI: https://doi.org/10.1016/j.trecan.2022.01.005