Professor Kairbaan Hodivala-Dilke
Deputy Institute Director, Professor of the Tumour Microenvironment
Cancers are composed of both tumour and stromal compartments. We are interested in understanding the molecular basis of how the tumour stroma contributes to tumour growth, therapy resistance and spread, in various solid tumours including lung cancers, pancreatic cancer and melanoma.
Dr Gabriela d’Amico Lago
My work is focused on understanding the roles of kinase and non-kinase motifs of FAK in controlling physiological angiogenesis in vivo. Overall my goal is to understand how to best control tumour blood vessels in the regulation of cancer.
Dr Jose Munoz-Felix
My main project is to use a CRIPSR screen to identify novel vascular promotion/chemosensitisation targets. Additionally, I am investigating the utility of this approach in the treatment of other fibrotic diseases.
Dr Rita Pedrosa
My work will identify other players in the regulation of angiocrine signalling using a CRISPR screen. I will also explore the molecular mechanisms underlying how FAK controls angiocrine signalling.
Dr Laura Wisniewski
My project looks at the modelling of cancer for improved therapy development. I am carrying out in vivo cancer experiments, with and without modifications of the tumour microenvironment, to examine effects of such treatments on anti-cancer therapy efficacy.