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Professor Nick Lemoine
Director, CRUK Barts Centre; Medical Director, NIHR Clinical Research Network; Professor of Molecular Oncology

I am the Director of Barts Cancer Institute. My groups’ primary research interests are in the genomics and molecular pathology of pancreatic cancer and the development of oncolytic virotherapy.

Professor Trevor Graham
Professor of Cancer Evolution

My lab measures the patterns of clonal evolution that define carcinogenesis and develops novel mathematical tools for analysis and prediction. By characterising tumour evolution, we aim to find better ways to determine prognosis and more effective ways to treat cancers.

Professor Claude Chelala
Co-Director, Centre for Computational Biology, LSI; Professor of Bioinformatics

My research interests lie in the area of translational bioinformatics. Current research projects are focused in high-throughput data analysis, integration with clinical data, databases and software development, particularly for pancreatic cancer and breast cancer.

Professor Pedro R. Cutillas
Professor of Cell Signalling and Proteomics

My research group uses unique proteomics and computational approaches to understand how cell signalling pathways driven by the activity of protein kinases contribute to the development of cancer. Increasing this knowledge will be invaluable in advancing personalised cancer therapies.

Dr Mirjana Efremova
Lecturer

We are interested in understanding the cellular and molecular mechanisms that promote cancer cell plasticity and adaptation of tumour cells in metastatic niches and under therapeutic pressure.

Dr Faraz Mardakheh
Lecturer

My lab utilises state-of-art multi-omics methodologies to study how protein synthesis is dysregulated in cancer cells, and how this dysregulation contributes to various stages of cancer progression.

Dr Jessica Okosun
Clinical Senior Lecturer

My research focuses on understanding the genetic and molecular mechanisms that underlie the initiation and progression of B-cell non-Hodgkin’s lymphomas in order to define clinically-relevant biomarkers.

Dr Jun Wang
Senior Lecturer

My main research interests lie in applying bioinformatics and computational approaches to analyse large-scale cancer datasets to uncover novel diagnostic and prognostic features. I also lead the CRUK Barts Centre Bioinformatics Core Facility.

Dr Maryam Abdollahyan

My research is focused on Machine Learning with applications in Bioinformatics and Health Informatics, and Data Management of the Breast Cancer Now Tissue Bank (BCNTB).

Dr Chinedu A. Anene
Bioinformatician

I am a bioinformatician and am currently developing a computer vision pipeline to quantify and characterise tumour hypoxia in squamous cell carcinomas.

Dr Findlay Redvers Bewicke-Copley

My work is currently focused on lymphoma, working on variant calling and gene expression analysis of NGS data.

Dr Emanuela Gadaleta

We are updating the bioinformatics data management system, expanding the analytical modules and functionalities, developing purpose-built graphical pug-ins and designing the bioinformatics infrastructure to allow the querying and analysis of data returned from projects using BCNTB tissues.

Dr Jacob Househam

I am a computational biologist focussing on understanding the evolutionary dynamics that underpin colorectal cancer progression.

Dr Faraz Khan
Bioinformatician

I am a Bioinformatician working on the development of pipelines for NGS data analysis, including mutational calling, Single-Cell RNA-seq, ChIP peak calling and methylation, variant annotation and prioritisation, as well as multi-layer data integration strategy and tools.

Dr Florian Laforets

My research in Prof Balkwill’s group focuses on imaging tumour-associated macrophages and other immune cells in live ex vivo tumour slices, in order to assess their behaviour and the impact of immunotherapies on the live tumour microenvironment.

Dr Eszter Lakatos

I apply bioinformatic techniques and mathematical modelling to understand the evolutionary processes in colorectal cancer. My research focuses on the trade-offs a growing tumour population has to face for efficient growth and survival.

Dr Eleni Maniati

My research project aims to integrate multi-omic molecular and histological data datasets of the microenvironment of HGSOC metastases. This work will allow us to identify key microenvironmental components and pathways that sustain and promote tumours.

Dr Maximilian Mossner

My research is focussed on the disturbed epigenomic landscape within pancreatic tumours.

In particular, I investigate the bi-directional epigenetic reprogramming between the tumour microenvironment and pancreatic cancer stem cells that leads to cooperative tumour outgrowth.

Dr Sam Ogden

We are using single cell multi-omic approaches to study how cancer cell plasticity and the tumour microenvironment contribute to metastasis in colorectal cancer.

Dr Jorge Oscanoa

I am developing SNPnexus, a software dedicated to improving our understanding of the functional role of genetic variations to prioritise clinically relevant ones facilitating the promise of precision medicine.

Dr Helen Ross-Adams

The aim of my work is to develop clinically-relevant biomarkers that could aid in earlier disease detection, predict treatment response, and inform clinical management of patients.

Dr Kunal Shah

I am studying how the tumour suppressor gene LIMD1 functions in the microRNA pathway, a gene regulatory pathway that is often dysregulated in cancer.

Dr Elly Tyler

My research investigates a specific composition of extracellular matrix molecules which may explain the difference between responders and non-responders to immunotherapy.

Dr Dayem Ullah
UKRI/Rutherford Research Fellow

My role focuses on the design and implementation of a data management system for a pancreatic tissue bank hosted by the Institute.

My interest also lies in the development of various web-based computational analyses and data mining tools for biological research.

Dr Louie van de Lagemaat

I use computational biology techniques to understand how normal RNA regulatory mechanisms used in development are hijacked in cancers.