I am the Director of CRUK Barts Centre. My groups' primary research interests are in the genomics and molecular pathology of pancreatic cancer and the development of oncolytic virotherapy.
Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent. Nat Commun (2017) 9;8(1):1395. PMID: 29123084
Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus. Gene Ther (2015) 22: 476-484. PMID: 25876464
A Vaccinia virus armed with interleukin-10 is a promising therapeutic agent for treatment of murine pancreatic cancer. Clin Cancer Res (2015) 21: 405-416. PMID: 25416195
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Med (2014) 6:105. PMID: 25587357
I work with Professor Claude Chelala and Dr Tatjana Crnogorac-Jurcevic on the genomics and molecular pathology of pancreatic cancer. We use global profiling approaches at the genomic and proteomic levels to identify targets that can be exploited for detection and treatment of this disease. We are also developing novel platforms and algorithms for the bioinformatic interrogation and interpretation of very large, multidimensional datasets.
I work with Professor Yaohe Wang and Dr Gunnel Halldén on the development of oncolytic virotherapy, an approach that uses adenoviruses and vaccinia viruses that selectively replicate within and kill cancer cells, but leave normal cells untouched. We are also working on defining the cell survival signalling circuits that determine the sensitivity of cancer cells to this approach. The role of the immune system in modulating viral replication and tumour cell destruction is the focus of a major new programme.
National and International Committees (current)
External scientific activities
Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene Cao D, Song Q, Li J et al. Molecular Therapy - Oncolytics (2022) 25(7) 264-275
Erratum: A virus-infected, reprogrammed somatic cell-derived tumor cell (VIReST) vaccination regime can prevent initiation and progression of pancreatic cancer (Clinical Cancer Research (2020) 26 (465-476) DOI: 10.1158/1078-0432.CCR-19-1395) Lu S, Zhang Z, Du P et al. Clinical Cancer Research (2021) 27(7) 2663
A Tumor-Targeted Replicating Oncolytic Adenovirus Ad-TD-nsIL12 as a Promising Therapeutic Agent for Human Esophageal Squamous Cell Carcinoma Zhang Z, Zhang C, Miao J et al. Cells (2020) 9(7)
Cancer gene therapy I: genetic intervention strategies Martin L-A, Lemoine NR (2020) (10) 255-275
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer Gadaleta E, Fourgoux P, Pirró S et al. npj Breast Cancer (2020) 6(1)
Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime Zhang Z, Lu S, Dunmall LSC et al. Frontiers in Immunology (2020) 11(7)
Erratum: A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery (J ImmunoTher Cancer (2020) 8 (e000415) DOI: 10.1136/jitc-2019-000415) Ahmed J, Chard LS, Yuan M et al. Journal for ImmunoTherapy of Cancer (2020) 8(7)
A new oncolytic v accinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery Ahmed J, Chard LS, Yuan M et al. Journal for ImmunoTherapy of Cancer (2020) 8(7)
Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus Ferguson MS, Chard Dunmall LS, Gangeswaran R et al. Molecular Therapy (2020) 28(1) 1263-1275
Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma Cutmore LC, Brown NF, Raj D et al. Pancreatology (2020) (1)For additional publications, please click here
I trained in medicine at St Bartholomew's Hospital Medical College where I qualified with the University of London Gold Medal in 1983, specialising in pathology and oncology with posts in London and Cardiff. I gained my PhD in molecular oncology in 1988 working on the molecular genetics of thyroid cancer at The University of Wales College of Medicine in Cardiff, and then my MD in molecular oncology in 1992 working on growth factor receptor abnormalities at the Royal Postgraduate Medical School, London.
I was Professor of Molecular Pathology at Imperial College London, where I was Director of the Cancer Research UK Molecular Oncology Unit and the first Director of the National Translational Cancer Research Centre at Hammersmith Hospital, before moving to become Director of the Barts Cancer Institute in 2005.
I am currently Chair of Trustees of the Medical Research Foundation (MRC’s independent charity), and Chair of funding and research strategy boards including the NIHR i4i Challenge Awards Panel, Diabetes UK Research Committee, Prostate Cancer UK Research Strategy Board, Pancreatic Cancer Research Fund Scientific Committee, Irish Health Board & Research Charities Committee. I am also a member of the MRC Stratified Medicine Expert Review Committee (Vice Chair), CR-UK Clinical Research Monitoring Committee, Pancreatic Cancer UK Scientific Advisory Committee, and the Lister Institute for Preventive Medicine.
I have previously been Chairman of the MRC Clinical Research & Career Development Panel and the NIHR Clinician Scientist Appointments & Review Panel. I chaired the MRC Stem Cell Fellowship Panel, the CR-UK Clinician Scientist and Senior Clinician Fellowship Panel and the MRC Experimental Medicine Review Panel for the Molecular & Cellular Medicine Board. I was a long-serving member of the Gene Therapy Advisory Committee at the Department of Health, as well as the CR-UK Science Funding Committee, MRC Molecular & Cellular Medicine Board, CORE Scientific Advisory Board and many other scientific review committees.
I was the Editor of the Nature Specialist Journal Gene Therapy for twenty years (1997- 2017), and my research into the molecular genetics of cancer and gene therapy has been funded by programme grants from MRC, Cancer Research UK, Digestive Cancer Campaign and the European Union. I was elected as a fellow of the Academy of Medical Sciences in 2006 and as a Foreign Academician of the Chinese Academy of Engineering in 2017. I was presented with the China National Friendship Award by Premier Li Keqiang of the Chinese Government in 2017.